Role of Ca2+-calmodulin dependent phospholamban phosphorylation on the relaxant effect of ?-adrenergic agonists

1993 ◽  
Vol 124 (1) ◽  
pp. 33-42 ◽  
Author(s):  
Leticia Vittone ◽  
Cecilia Mundi�a ◽  
Gladys Chiappe de Cingolani ◽  
Alicia Mattiazzi
Keyword(s):  
Adrenergic Agonists ◽  
Relaxant Effect ◽  
Phospholamban Phosphorylation

Dissociation between contraction and relaxation: The possible role of phospholamban phosphorylation

1987 ◽  
Vol 82 (6) ◽  
pp. 507-516 ◽  
Author(s):  
C. Mundiña Weilenmann ◽  
L. Vittone ◽  
G. Cingolani ◽  
A. Mattiazzi
Keyword(s):  
Contraction And Relaxation ◽  
Phospholamban Phosphorylation

Arteriolar tone is determined by activity of ATP-sensitive potassium channels

1993 ◽  
Vol 265 (5) ◽  
pp. H1797-H1803 ◽  
Author(s):  
W. F. Jackson
Keyword(s):  
Potassium Channels ◽  
Intravital Microscopy ◽  
Cheek Pouch ◽  
Cremaster Muscle ◽  
Adrenergic Agonists ◽  
Beta Adrenergic Agonists ◽  
Muscle Concentration ◽  
Arteriolar Tone ◽  
Arteriolar Vasodilation

The role of ATP-sensitive potassium channels (KATP) in determining resting arteriolar tone and vasodilator reactivity was assessed in superfused, hamster microcirculatory beds studied via intravital microscopy. Under resting conditions, the selective KATP blocker, glibenclamide, produced concentration-dependent vasoconstriction in both the cheek pouch and the cremaster muscle. Concentration-related constriction of cheek pouch arterioles was also observed with tetrapentylammonium, although this agent appeared to have toxic effects on the microcirculation. Glibenclamide (2 microM) abolished arteriolar vasodilation to cromakalim and pinacidil over a concentration range (10 nM-1 microM) in which these agents are selective KATP agonists and also significantly inhibited adenosine-, carbacyclin-, and isoproterenol-induced vasodilation. In contrast, responses to other vasodilators were not significantly affected [methacholine, forskolin, and dibutyryl adenosine 3',5'-cyclic monophosphate (cAMP)] or only slightly depressed (sodium nitroprusside). Thus the activity of KATP determines, in part, resting arteriolar tone in the hamster. Furthermore, vasodilators like adenosine, beta-adrenergic agonists, and prostacyclin appear to act through these ion channels by a mechanism that may not involve cAMP.

scholarly journals Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent

2020 ◽  
Vol 21 (7) ◽  
pp. 2597 ◽  
Author(s):  
Laura Rombolà ◽  
Damiana Scuteri ◽  
Chizuko Watanabe ◽  
Shinobu Sakurada ◽  
Kengo Hamamura ◽  
...  
Keyword(s):  
Essential Oil ◽  
Elevated Plus Maze ◽  
Relaxant Effect ◽  
Serotonergic Receptors ◽  
Selective Agonist ◽  
Plus Maze ◽  
Way 100635 ◽  
Pharmacological Data ◽  
Citrus Bergamia

The essential oil obtained by the fresh fruit of Citrus bergamia Risso et Poiteau is used worldwide in aromatherapy to reduce pain, facilitate sleep induction, and/or minimize the effects of stress-induced anxiety. Preclinical pharmacological data demonstrate that bergamot essential oil (BEO) modulates specific neurotransmissions and shows an anxiolytic-relaxant effect not superimposable to that of the benzodiazepine diazepam, suggesting that neurotransmissions, other than GABAergic, could be involved. Several studies on essential oils indicate a role for serotonergic (5-HT) neurotransmission in anxiety. Interestingly, among serotonergic receptors, the 5-HT1A subtype seems to play a key role in the control of anxiety. Here, we report that modulation of the 5-HT1A receptor by selective agonist ((±)8-OH-DPAT) or antagonist (WAY-100635) may influence some of the anxiolytic-relaxant effects of BEO in Open Field and Elevated Plus Maze tests.

scholarly journals The action of α-adrenergic agonists on plasma-membrane calcium fluxes in perfused rat liver

1984 ◽  
Vol 220 (1) ◽  
pp. 43-50 ◽  
Author(s):  
P H Reinhart ◽  
W M Taylor ◽  
F L Bygrave
Keyword(s):  
Plasma Membrane ◽  
Rat Liver ◽  
Potential Role ◽  
Dependent Manner ◽  
Perfused Rat Liver ◽  
Adrenergic Agonists ◽  
Mediated Effects ◽  
Alpha Agonist ◽  
Alpha Adrenergic Agonist

The effect of alpha-adrenergic agonists on Ca2+ fluxes was examined in the perfused rat liver by using a combination of Ca2+-electrode and 45Ca2+-uptake techniques. We showed that net Ca2+ fluxes can be described by the activities of separate Ca2+-uptake and Ca2+-efflux components, and that alpha-adrenergic agonists modulate the activity of both components in a time-dependent manner. Under resting conditions, Ca2+-uptake and -efflux activities are balanced, resulting in Ca2+ cycling across the plasma membrane. The alpha-adrenergic agonists vasopressin and angiotensin, but not glucagon, stimulate the rate of both Ca2+ efflux and Ca2+ uptake. During the first 2-3 min of alpha-agonist administration the effect on the efflux component is the greater, the net effect being efflux of Ca2+ from the cell. After 3-4 min of phenylephrine treatment, net Ca2+ movements are essentially complete, however, the rate of Ca2+ cycling is significantly increased. After removal of the alpha-agonist a large stimulation of the rate of Ca2+ uptake leads to the net accumulation of Ca2+ by the cell. The potential role of these Ca2+ flux changes in the expression of alpha-adrenergic-agonist-mediated effects is discussed.

Analysis of the Role of Nitric Oxide in the Relaxant Effect of the Crude Extract and Fractions from Eugenia uniflora in the Rat Thoracic Aorta

1997 ◽  
Vol 49 (4) ◽  
pp. 433-437 ◽  
Author(s):  
ELISABETH WAZLAWIK ◽  
MARCO ANTÔNIO SILVA ◽  
RODRIGO REBELO PETERS ◽  
JOãO FRANCISCO GOMES CORREIA ◽  
MARENI ROCHA FARIAS ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Thoracic Aorta ◽  
Crude Extract ◽  
Relaxant Effect ◽  
Eugenia Uniflora ◽  
Rat Thoracic Aorta
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