Feasibility of low-dose and intermittent chenodeoxycholic acid therapy of gallstones

1977 ◽  
Vol 22 (10) ◽  
pp. 856-860 ◽  
Author(s):  
J. W. Marks ◽  
G. G. Bonorris ◽  
A. Chung ◽  
M. J. Coyne ◽  
R. Okun ◽  
...  
Keyword(s):  
Chenodeoxycholic Acid ◽  
Low Dose ◽  
Acid Therapy

Changes in electrical potential difference of rectal mucosa and of gallbladder bile constituents of dogs fed chenodeoxycholic acid

1986 ◽  
Vol 64 (8) ◽  
pp. 1115-1118
Author(s):  
J. Patrick Shoenut
Keyword(s):  
Chenodeoxycholic Acid ◽  
Dose Group ◽  
Low Dose ◽  
Electrical Potential ◽  
Rectal Mucosa ◽  
Gallbladder Bile ◽  
Potential Difference ◽  
Control Group ◽  
Electrical Potential Difference ◽  
Dissolution Studies

Eighteen dogs were studied for 54 days. Rectal mucosal electrical potential difference (PD), gallbladder bile acids, cholesterol, and phospholipids were measured. It was shown that feeding chenodeoxycholic acid (CDCA) for 24 days in dosages of 15, 30, and 60 mg/kg of body weight, all depressed PD equally but significantly (P < 0.05) in three groups of dogs compared with a control group. This depression was reversible 24 days after CDCA ingestion ceased in the two highest dosages. The low dose group was sacrificed after 24 days of CDCA feeding and the gallbladder bile was analyzed. CDCA and cholesterol were each significantly (P < 0.05) elevated over control values in the gallbladder bile of these dogs. Phospholipids were not significantly changed. The PD, a reflection of Na+–K+ ATPase activity, may be a useful indicator in maximizing dosages of CDCA in gallstone dissolution studies.

scholarly journals Cyclic AMP and cyclic GMP levels in human colonic mucosa before and during chenodeoxycholic acid therapy.

Gut ◽  
1979 ◽  
Vol 20 (6) ◽  
pp. 489-492 ◽  
Author(s):  
G R Corazza ◽  
R Ciccarelli ◽  
F Caciagli ◽  
G Gasbarrini
Keyword(s):  
Cyclic Amp ◽  
Chenodeoxycholic Acid ◽  
Cyclic Gmp ◽  
Colonic Mucosa ◽  
Acid Therapy

scholarly journals Chenodeoxycholic acid therapy for hypertriglyceridaemia in men.

1978 ◽  
Vol 5 (3) ◽  
pp. 249-254 ◽  
Author(s):  
MC Bateson ◽  
D Maclean ◽  
JR Evans ◽  
IA Bouchier
Keyword(s):  
Chenodeoxycholic Acid ◽  
Acid Therapy

Homocysteine, malondialdehyde and endothelial markers in dialysis patients during low-dose folinic acid therapy

2002 ◽  
Vol 252 (5) ◽  
pp. 456-464 ◽  
Author(s):  
T. Apeland ◽  
M. A. Mansoor ◽  
I. Seljeflot ◽  
I. Bronstad ◽  
L. Goransson ◽  
...  
Keyword(s):  
Folinic Acid ◽  
Low Dose ◽  
Dialysis Patients ◽  
Acid Therapy ◽  
Endothelial Markers
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