Changes in plasma motilin concentration and gastrointestinal contractile activity in conscious dogs

1978 ◽  
Vol 23 (10) ◽  
pp. 929-935 ◽  
Author(s):  
Zen Itoh ◽  
Shinjin Takeuchi ◽  
Isamu Aizawa ◽  
Kohzaburo Mori ◽  
Tomohiko Taminato ◽  
...  
Keyword(s):  
Contractile Activity ◽  
Conscious Dogs ◽  
Plasma Motilin ◽  
Gastrointestinal Contractile Activity

The effect of growth hormone releasing peptide-2 on upper gastrointestinal contractile activity and food intake in conscious dogs

2009 ◽  
Vol 44 (4) ◽  
pp. 297-304 ◽  
Author(s):  
Katsuyoshi Kudoh ◽  
Chikashi Shibata ◽  
Yuji Funayama ◽  
Kouhei Fukushima ◽  
Tatsuya Ueno ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Food Intake ◽  
Contractile Activity ◽  
Conscious Dogs ◽  
Gastrointestinal Contractile Activity ◽  
Upper Gastrointestinal

Erythromycin mimics exogenous motilin in gastrointestinal contractile activity in the dog

1984 ◽  
Vol 247 (6) ◽  
pp. G688-G694 ◽  
Author(s):  
Z. Itoh ◽  
M. Nakaya ◽  
T. Suzuki ◽  
H. Arai ◽  
K. Wakabayashi
Keyword(s):  
Small Intestine ◽  
Gastrointestinal Tract ◽  
Intravenous Infusion ◽  
Contractile Activity ◽  
Contractile Force ◽  
Naturally Occurring ◽  
Gastrointestinal Motor ◽  
Plasma Motilin ◽  
Interdigestive Migrating Contractions ◽  
Gastrointestinal Contractile Activity

The gastrointestinal motor stimulating activity of erythromycin (EM) was studied in conscious dogs. It was found that a 20-min intravenous infusion of EM lactobionate at a dose of 50–100 micrograms (potency) X kg-1 X h-1 induced a group of strong contractions in the stomach and the duodenum, and the contractions migrated along the small intestine to the terminal ileum. The EM-induced contractions were quite similar to the naturally occurring interdigestive migrating contractions (IMC) in the gastrointestinal tract in frequency, contractile force, and duration of the contractions, migrating velocity, and accompanying peaks of plasma motilin concentration. The EM-induced contractions in the stomach were inhibited by feeding and intravenous infusion of pentagastrin (1.5 micrograms X kg-1 X h-1) but were not affected by secretin; these findings are identical to those found with the naturally occurring and motilin-induced contractions. Like motilin, EM stimulated motor activity only during the interdigestive state. We conclude that EM induces IMC associated with the release of endogenous motilin in the dog.

Effects of Mitemcinal (GM-611), an Acid-Resistant Nonpeptide Motilin Receptor Agonist, on the Gastrointestinal Contractile Activity in Conscious Dogs

Pharmacology ◽  
2007 ◽  
Vol 79 (4) ◽  
pp. 223-235 ◽  
Author(s):  
Ken-ichi Ozaki ◽  
Kenji Yogo ◽  
Hirokazu Sudo ◽  
Mitsu Onoma ◽  
Kenshi Kamei ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Contractile Activity ◽  
Conscious Dogs ◽  
Motilin Receptor ◽  
Gastrointestinal Contractile Activity

Effects of Motilin and Mitemcinal (GM-611) on Gastrointestinal Contractile Activity in Rhesus Monkeys In Vivo and In Vitro

2007 ◽  
Vol 52 (11) ◽  
pp. 3112-3122 ◽  
Author(s):  
Kenji Yogo ◽  
Ken-ichi Ozaki ◽  
Hisanori Takanashi ◽  
Masao Koto ◽  
Zen Itoh ◽  
...  
Keyword(s):  
Rhesus Monkeys ◽  
Contractile Activity ◽  
Gastrointestinal Contractile Activity

Effect of TKS159, a novel 5‐hydroxytryptamine4agonist, on gastric contractile activity in conscious dogs

1998 ◽  
Vol 10 (4) ◽  
pp. 295-303 ◽  
Author(s):  
HAGA ◽  
SUZUKI ◽  
SHIBA ◽  
MOCHIKI ◽  
MIZUMOTO ◽  
...  
Keyword(s):  
Contractile Activity ◽  
Conscious Dogs
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