Response to 30 generations of selection for open-field activity in laboratory mice

1978 ◽  
Vol 8 (1) ◽  
pp. 3-13 ◽  
Author(s):  
J. C. DeFries ◽  
Mary Cook Gervais ◽  
E. A. Thomas
Keyword(s):  
Open Field ◽  
Laboratory Mice ◽  
Open Field Activity ◽  
Field Activity ◽  
Selection For

scholarly journals Quantitative Trait Locus Mapping in Laboratory Mice Derived From a Replicated Selection Experiment for Open-Field Activity

Genetics ◽  
2001 ◽  
Vol 158 (3) ◽  
pp. 1217-1226
Author(s):  
Maria Grazia Turri ◽  
Norman D Henderson ◽  
John C DeFries ◽  
Jonathan Flint
Keyword(s):  
Open Field ◽  
Selection Experiment ◽  
Laboratory Mice ◽  
Open Field Activity ◽  
Field Activity ◽  
Selection For ◽  
Trait Locus ◽  
Locus Mapping ◽  
Bidirectional Selection ◽  
Haplotype Information

Abstract Bidirectional selection in rodents has been used to derive animal models of human behavior. An important question is whether selection for behavior operates on a limited number of QTL or whether the number and individual contribution of QTL varies between selection experiments. To address this question, we mapped QTL in two large F2 intercrosses (N = 815 and 821) from the four lines derived from a replicated selection experiment for open-field activity, an animal model for susceptibility to anxiety. Our analyses indicate that selection operated on the same relatively small number of loci in both crosses. Haplotype information and the direction of effect of each QTL allele were used to confirm that the QTL mapped in the two crosses lie in the same chromosomal regions, although we were unable to determine whether QTL in the two crosses represent the same genes. We conclude that the genetic architecture of the selected strains is similar and relatively simple.

Response to 20 generations of selection for open-field activity in mice

1974 ◽  
Vol 11 (4) ◽  
pp. 481-495 ◽  
Author(s):  
J.C. Defries ◽  
J.P. Hegmann ◽  
R.A. Halcomb
Keyword(s):  
Open Field ◽  
Open Field Activity ◽  
Field Activity ◽  
Selection For

The ethanol-induced open-field activity in rodents treated with isethionic acid, a central metabolite of taurine

Life Sciences ◽  
1999 ◽  
Vol 64 (18) ◽  
pp. 1613-1621 ◽  
Author(s):  
Marta Miquel ◽  
Mercé Correa ◽  
Carles Sanchis-Segura ◽  
Carlos M.G. Aragon
Keyword(s):  
Open Field ◽  
Open Field Activity ◽  
Field Activity ◽  
Isethionic Acid

An open-field activity analysis of labyrinthectomized rats

1990 ◽  
Vol 48 (1) ◽  
pp. 27-30 ◽  
Author(s):  
Jennifer D. Porter ◽  
Sergio M. Pellis ◽  
Merle E. Meyer
Keyword(s):  
Open Field ◽  
Activity Analysis ◽  
Open Field Activity ◽  
Field Activity
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