Corticofugal influences on reticulospinal neurons of the gigantocellular nucleus in cats

1977 ◽  
Vol 8 (3) ◽  
pp. 192-199
Author(s):  
A. I. Pilyavskii
Keyword(s):  
Reticulospinal Neurons ◽  
Gigantocellular Nucleus

Fastigial nucleus-mediated respiratory responses depend on the medullary gigantocellular nucleus

2001 ◽  
Vol 91 (4) ◽  
pp. 1713-1722 ◽  
Author(s):  
Fadi Xu ◽  
Tongrong Zhou ◽  
Tonya Gibson ◽  
Donald T. Frazier
Keyword(s):  
Electrical Stimulation ◽  
Ibotenic Acid ◽  
Major Effect ◽  
Fastigial Nucleus ◽  
Respiratory Response ◽  
The Right ◽  
Spontaneously Breathing ◽  
Respiratory Responses ◽  
Gigantocellular Nucleus ◽  
Stimulation Of

Electrical stimulation of the rostral fastigial nucleus (FNr) alters respiration via activation of local neurons. We hypothesized that this FNr-mediated respiratory response was dependent on the integrity of the nucleus gigantocellularis of the medulla (NGC). Electrical stimulation of the FNr in 15 anesthetized and tracheotomized spontaneously breathing rats significantly altered ventilation by 35.2 ± 11.0% ( P < 0.01) with the major effect being excitatory (78%). This respiratory response did not significantly differ from control after lesions of the NGC via bilateral microinjection of kainic or ibotenic acid (4.5 ± 1.9%; P > 0.05) but persisted in sham controls. Eight other rats, in which horseradish peroxidase (HRP) solution was previously microinjected into the left NGC, served as nonstimulation controls or were exposed to either 15-min repeated electrical stimulation of the right FNr or hypercapnia for 90 min. Histochemical and immunocytochemical data showed that the right FNr contained clustered HRP-labeled neurons, most of which were double labeled with c-Fos immunoreactivity in both electrically and CO2-stimulated rats. We conclude that the NGC receives monosynaptic FNr inputs and is required for fully expressing FNr-mediated respiratory responses.

Responses of medullary reticulospinal neurons to sinusoidal stimulation of labyrinth receptors in decerebrate cat

1983 ◽  
Vol 50 (5) ◽  
pp. 1059-1079 ◽  
Author(s):  
D. Manzoni ◽  
O. Pompeiano ◽  
G. Stampacchia ◽  
U. C. Srivastava
Keyword(s):  
Phase Angle ◽  
Intermediate Phase ◽  
Longitudinal Axis ◽  
Peak Amplitude ◽  
Slow Rotation ◽  
Medullary Reticular Formation ◽  
Peak Displacement ◽  
Decerebrate Cat ◽  
Reticulospinal Neurons ◽  
Stimulation Of

The electrical activity of 168 individual neurons located in the medullary reticular formation, namely, in the medial aspects of the nucleus reticularis gigantocellularis, magnocellularis, and ventralis, has been recorded in precollicular decerebrate cats during sinusoidal tilt about the longitudinal axis of the whole animal, leading to stimulation of labyrinth receptors. In particular, 93 neurons were activated antidromically by stimulation of the spinal cord at T12 and L1 (1RS neurons); the remaining 75 neurons were not activated antidromically (RF neurons). Among these medial reticular neurons tested, 64 of 93 (i.e., 69%) 1RS neurons and 49 of 75 (i.e., 65%) RF neurons responded to slow rotation of the animal at the standard frequency of 0.026 Hz and at the peak amplitude of displacement of 10 degrees. A periodic modulation of firing rate of the units was observed during the sinusoidal stimulus. In particular, 71 of 113 units (i.e., 63%) were excited during side-up and depressed during side-down tilt, whereas 24 of 113 units (i.e., 21%) showed the opposite behavior. In both instances, the peak of the responses occurred with an average phase lead of about +25 degrees with respect to the extreme side-up or side-down position of the animal. The remaining 18 units (i.e., 16%) showed a prominent phase shift of the peak of their response with respect to animal position. Within the explored region of the medulla, the proportion of units excited during side-up tilt was higher at caudal levels, whereas that of the units excited during side-down tilt was higher at rostral levels. Units displaying intermediate phase angle of the responses predominated at intermediate levels of the medulla. Responses to animal tilt were detectable at 1 degree of peak displacement. The gain (impulses x s-1 x deg-1) of the responses of reticulospinal neurons did not change by increasing the peak amplitude of tilt from 5 to 20 degrees at the fixed frequency of 0.026 Hz. This finding indicates that the system was relatively linear with respect to the amplitude of displacement. By varying the frequency of stimulation from 0.008 to 0.32 Hz at the fixed amplitude of 10 degrees, two populations of reticulospinal neurons were observed. In the first, the gain and the phase angle of response remained relatively unmodified against changes in frequencies: these positional responses were attributed to stimulation of macular receptors.(ABSTRACT TRUNCATED AT 400 WORDS)

Discharge properties of pontine reticulospinal neurons during sleep-waking cycle

1978 ◽  
Vol 41 (3) ◽  
pp. 821-834 ◽  
Author(s):  
P. W. Wyzinski ◽  
R. W. McCarley ◽  
J. A. Hobson
Keyword(s):  
Spinal Cord ◽  
Firing Rate ◽  
Neuronal Population ◽  
Spinal Reflex ◽  
Reticular Nucleus ◽  
Medullary Reticular Formation ◽  
Reticulospinal Neurons ◽  
Reflex Pathways ◽  
Naturally Occurring ◽  
Generator Function

1. Reticulospinal neurons were identified by antidromic invasion from spinal cord electrodes chronically implanted at C4 in cats. 2. Most of the neuronal population studied lay within the medial portion of the giant cell field from the anterior pontine and to the anterior medullary reticular formation (FTG). A few cells were found in the tegmental reticular nucleus (TRC) which has not previously been known to project to the spinal cord. 3. Extracellular action potentials from the neuronal somata of the identified neurons were recorded continuously throughout naturally occurring sleep-waking cycles. 4. The identified reticulospinal neurons shared three properties, suggesting a generator function in desynchronized sleep (D) (with previously recorded but unidentified FTG neurons): selectivity (or concentration of discharge in D); tonic latency (or firing rate increases beginning several minutes prior to D); and phasic latency (or firing rate increases occurring prior to eye movements within D). 5. The location, discharge properties, and spinal projections of FTG neurons are, thus, all consistent with the hypothesis that they may directly mediate some of the descending excitatory and inhibitory influences on spinal reflex pathways in desynchronized sleep.

Adrenoceptor-Mediated Post- and Pre-Synaptic Regulations of the Reticulospinal Neurons in Rat Caudal Pontine Reticular Nucleus

2015 ◽  
Vol 53 (10) ◽  
pp. 7089-7106
Author(s):  
Nian Yang ◽  
Qi-Cheng Qiao ◽  
Yu-Hui Liu ◽  
Ji-Qiang Zhang ◽  
Zhi-An Hu ◽  
...  
Keyword(s):  
Reticular Nucleus ◽  
Reticulospinal Neurons
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