The application of brain capillary permeability coefficient measurements to pathological conditions and the selection of agents which cross the blood-brain barrier

1976 ◽  
Vol 4 (6) ◽  
pp. 499-519 ◽  
Author(s):  
Victor A. Levin ◽  
Herbert D. Landahl ◽  
Mary A. Freeman-Dove
Keyword(s):  
Blood Brain Barrier ◽  
Permeability Coefficient ◽  
Capillary Permeability ◽  
Brain Barrier ◽  
Brain Capillary ◽  
Pathological Conditions ◽  
Blood Brain ◽  
Selection Of

Blood–brain barrier and blood–cerebrospinal fluid barrier in normal and pathological conditions

2016 ◽  
Vol 33 (2) ◽  
pp. 89-96 ◽  
Author(s):  
Masaki Ueno ◽  
Yoichi Chiba ◽  
Ryuta Murakami ◽  
Koichi Matsumoto ◽  
Machi Kawauchi ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Pathological Conditions ◽  
Blood Brain

Receptor-mediated transcytosis of transferrin through blood-brain barrier endothelial cells

1996 ◽  
Vol 270 (4) ◽  
pp. H1149-H1158 ◽  
Author(s):  
L. Descamps ◽  
M. P. Dehouck ◽  
G. Torpier ◽  
R. Cecchelli
Keyword(s):  
Endothelial Cells ◽  
Blood Brain Barrier ◽  
Bovine Brain ◽  
Brain Barrier ◽  
Double Labeling ◽  
Brain Capillary ◽  
Brain Capillary Endothelial Cells ◽  
Blood Brain ◽  
Capillary Endothelial Cells ◽  
A Cell

A cell culture model of the blood-brain barrier consisting of a coculture of bovine brain capillary endothelial cells (BBCECs) and astrocytes has been used to examine the mechanism of iron transport to the brain. Binding experiments showed that BBCECs express 35,000 high-affinity (concn at 50% receptor saturation = 11.3 +/- 2.1 nM) transferin (Tf) receptors per cell. In contrast to apo-transferrin (apoTf) we observed a specific transport of holo-transferrin (holoTf) across BBCECs. This transport was inhibited completely at low temperature. Moreover, the anti-Tf receptor antibody (OX-26) competitively inhibited holoTf uptake by BBCECs. Pulse-chase experiments demonstrated that only 10% of Tf was recycled to the luminal side of the cells, whereas the majority of Tf was transcytosed to the abluminal side; double-labeling experiments clearly demonstrated that iron crosses BBCECs bound to Tf. No intraendothelial degradation of Tf was observed, suggesting that the intraendothelial pathway through BBCECs bypasses the lysosomal compartment. These results clearly show that the iron-Tf complex is transcytosed across brain capillary endothelial cells by a receptor-mediated pathway without any degradation.

Mathematical modeling and simulation of molecular mass transfer across blood brain barrier in brain capillary

2020 ◽  
Vol 310 ◽  
pp. 113254 ◽  
Author(s):  
Majid Hassanzadeganroudsari ◽  
M. Soltani ◽  
Amir Heydarinasab ◽  
Ali Taghvaie Nakhjiri ◽  
M.D. Kamal Hossain ◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
Mass Transfer ◽  
Modeling And Simulation ◽  
Molecular Mass ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Brain Capillary ◽  
Blood Brain
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