Effect of adequate stimulation on the discharge pattern of an isolated frog muscle spindle

1977 ◽  
Vol 8 (4) ◽  
pp. 326-332
Author(s):  
I. S. Poshina ◽  
T. A. Adzhimolaev ◽  
R. A. Durinyan
Keyword(s):  
Muscle Spindle ◽  
Frog Muscle ◽  
Discharge Pattern ◽  
Adequate Stimulation

Effects of calcium blockers on the discharge pattern of frog muscle spindle

1981 ◽  
Vol 218 (1-2) ◽  
pp. 388-392 ◽  
Author(s):  
F. Ito ◽  
Y. Komatsu ◽  
N. Katsuta
Keyword(s):  
Muscle Spindle ◽  
Frog Muscle ◽  
Discharge Pattern ◽  
Calcium Blockers

Action potential patterns of isolated frog muscle spindle in response to sinusoidal stimulation

1985 ◽  
Vol 53 (1) ◽  
pp. 76-88 ◽  
Author(s):  
H. Querfurth
Keyword(s):  
Muscle Spindle ◽  
Action Potentials ◽  
Dynamic Range ◽  
Modulation Depth ◽  
Phase Locking ◽  
Receptor Potential ◽  
Intermediate Frequency ◽  
Frequency Domain Analysis ◽  
Frog Muscle ◽  
Discharge Pattern

Signal transfer in the isolated frog muscle spindle is investigated using the linear frequency domain analysis technique. Sinusoidal stretches of different amplitudes (20-120 micron) and frequencies (0.1-120 Hz) were applied at different levels of static prestretch, ranging from resting length (L0) up to L0 + 400 micron, so that the frequency-response characteristics were measured at different operating points within the dynamic range. The neuronal responses were recorded from the first node of the afferent stem fiber with a modified air-gap technique. By this means, subthreshold receptor potentials, prepotentials preceding the impulse, and the propagated action potentials were recorded simultaneously, thus providing a detailed insight into the encoding process. There is a well-defined dynamic range of receptor responses. At L0, the encoding site is depolarized to its firing level and discharges spontaneous stimulus-independent impulses. The upper limit is given by the saturation of the receptor potential, which keeps the depolarization maximum below the level of sodium inactivation. Therefore a "depolarization block" or "overstretch" does not exist in the muscle spindle; i.e., the receptor retains its ability to encode information over a large range of dynamic and static displacements. Since the dynamic curves of the receptor potential are not symmetrical about their static operating point, the impulse pattern remains modulated throughout the dynamic range, even if small sinusoids are superimposed on a large static prestretch. The afferent discharge pattern is mainly regulated by the modulated AC component of the receptor potential. At low stimulus frequencies (less than 1 Hz) the receptor potential modulates almost linearly about the mean membrane voltage, so that the evoked discharge pattern displays a smooth analog signal, which is close to sinusoidal. Increasing the static prestretch increases both the peak response and the modulation depth of the impulse pattern. In the intermediate frequency range (1-10 Hz), the cycle histogram disintegrates into discrete peaks separated by empty bins, because the nonlinear receptor potential elicites firmly phase-locked action potentials during its fast depolarization transient. Raising the prestretch level improves the precision of phase locking and increases the number of spikes elicited per cycle.(ABSTRACT TRUNCATED AT 400 WORDS)

Calcium spikes in frog muscle spindle

1979 ◽  
Vol 11 ◽  
pp. 2
Author(s):  
Fumio Ito ◽  
Tadashi Akaike ◽  
Yukio Komatsu
Keyword(s):  
Muscle Spindle ◽  
Frog Muscle ◽  
Calcium Spikes

Effects of Intracellular Ca2+ on the Frog Muscle Spindle in Relation to Cyclic AMP Action

1988 ◽  
pp. 195-199 ◽  
Author(s):  
Fumio Ito ◽  
Masahiro Sokabe ◽  
Falih Hassan Diwan ◽  
Noriaki Fujitsuka ◽  
Atsushi Yoshimura
Keyword(s):  
Cyclic Amp ◽  
Muscle Spindle ◽  
Frog Muscle
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