Membrane currents in the rabbit sinoatrial node cell as studied by the double microelectrode method

1976 ◽  
Vol 364 (1) ◽  
pp. 45-52 ◽  
Author(s):  
Akinori Noma ◽  
Hiroshi Irisawa
Keyword(s):  
Sinoatrial Node ◽  
Membrane Currents ◽  
Sinoatrial Node Cell ◽  
Rabbit Sinoatrial Node

A mathematical model of a rabbit sinoatrial node cell

1994 ◽  
Vol 266 (3) ◽  
pp. C832-C852 ◽  
Author(s):  
S. S. Demir ◽  
J. W. Clark ◽  
C. R. Murphey ◽  
W. R. Giles
Keyword(s):  
Mathematical Model ◽  
Sinoatrial Node ◽  
Surface Membrane ◽  
Recent Experimental Data ◽  
Pacemaker Cells ◽  
Diffusion Limited ◽  
Electrophysiological Responses ◽  
Sinoatrial Node Cell ◽  
Rabbit Sinoatrial Node

A mathematical model for the electrophysiological responses of a rabbit sinoatrial node cell that is based on whole cell recordings from enzymatically isolated single pacemaker cells at 37 degrees C has been developed. The ion channels, Na(+)-K+ and Ca2+ pumps, and Na(+)-Ca2+ exchanger in the surface membrane (sarcolemma) are described using equations for these known currents in mammalian pacemaker cells. The extracellular environment is treated as a diffusion-limited space, and the myoplasm contains Ca(2+)-binding proteins (calmodulin and troponin). Original features of this model include 1) new equations for the hyperpolarization-activated inward current, 2) assessment of the role of the transient-type Ca2+ current during pacemaker depolarization, 3) inclusion of an Na+ current based on recent experimental data, and 4) demonstration of the possible influence of pump and exchanger currents and background currents on the pacemaker rate. This model provides acceptable fits to voltage-clamp and action potential data and can be used to seek biophysically based explanations of the electrophysiological activity in the rabbit sinoatrial node cell.

scholarly journals Kinetics and rectification of the slow inward current in the rabbit sinoatrial node cell.

1981 ◽  
Vol 31 (4) ◽  
pp. 491-500 ◽  
Author(s):  
Akinori NOMA ◽  
Hiroshi KOTAKE ◽  
Shinichiro KOKUBUN ◽  
Hiroshi IRISAWA
Keyword(s):  
Sinoatrial Node ◽  
Slow Inward Current ◽  
Inward Current ◽  
Sinoatrial Node Cell ◽  
Rabbit Sinoatrial Node

Inward current of the rabbit sinoatrial node cell

1977 ◽  
Vol 372 (1) ◽  
pp. 43-51 ◽  
Author(s):  
A. Noma ◽  
K. Yanagihara ◽  
H. Irisawa
Keyword(s):  
Sinoatrial Node ◽  
Inward Current ◽  
Sinoatrial Node Cell ◽  
Rabbit Sinoatrial Node
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