Number of exponential terms describing the solution of anN- compartmental mammillary model: Vanishing exponentials

1979 ◽  
Vol 7 (5) ◽  
pp. 511-525 ◽  
Author(s):  
D. P. Vaughan ◽  
M. J. Dennis
Keyword(s):  
Mammillary Model

A four compartment linear mammillary model

1987 ◽  
Vol 20 (1-2) ◽  
pp. 27-33
Author(s):  
Y. Cherruault ◽  
V.B. Sarin
Keyword(s):  
Mammillary Model

Compartment analysis of metabolism of chromium(III) in rats of various ages.

1977 ◽  
Vol 232 (5) ◽  
pp. E478 ◽  
Author(s):  
C Onkelinx
Keyword(s):  
Intravenous Injection ◽  
Wistar Rats ◽  
Age Group ◽  
Compartment Analysis ◽  
Single Intravenous Injection ◽  
Female Wistar Rats ◽  
Disappearance Curve ◽  
Plasma Disappearance Curve ◽  
Mammillary Model

The metabolism of chromium(III) was studied in groups of female Wistar rats of various ages (35, 60, and 120 days) after a single intravenous injection of 51CrCl3 in trace amounts. In all the animals, the plasma disappearance curve could be adequately described by a sum of three exponential terms between 0 and 265 h postinjection. A three-compartment mammillary model is proposed that permits the description of Cr(III) metabolism in quantitative terms. The model defines compartment volumes, clearances by exchange, and clearances by excretion. The total excretory clearance is the sum of three components: urinary clearance (fu), fecal clearance (fd), and a residual clearance (fs), corresponding to an apparently irreversible deposition of chromium into long term body reservoirs. The parameters of the model are reported for each age group; when their values are expressed per 100 g of body wt, all the components of the excretory clearance decrease with age. In all cases elimination takes place primarily via the urine and fs accounts for 31-41% of the total excretory clearance. Consistent with the model, 51Cr was found to accumulate with time in several organs such as bone, kidney, spleen, and liver after a single intravenous injection of 51CrCl3.

A FIVE COMPARTMENT LINEAR MAMMILLARY MODEL

Kybernetes ◽  
1987 ◽  
Vol 16 (4) ◽  
pp. 247-250 ◽  
Author(s):  
Y. CHERRUAULT ◽  
V.B. SARIN
Keyword(s):  
Mammillary Model

Association between plasma zinc concentration and zinc kinetic parameters in premenopausal women

2003 ◽  
Vol 285 (5) ◽  
pp. E1010-E1020 ◽  
Author(s):  
Katsuhiko Yokoi ◽  
Norman G. Egger ◽  
V. M. Sadagopa Ramanujam ◽  
Nancy W. Alcock ◽  
Hari H. Dayal ◽  
...  
Keyword(s):  
Kinetic Parameters ◽  
Zinc Concentration ◽  
Premenopausal Women ◽  
Plasma Zinc ◽  
Lower Plasma ◽  
Breakfast Cereal ◽  
Break Points ◽  
Zn Status ◽  
Taste Detection ◽  
Mammillary Model

The objective of this study was to measure relationships between plasma zinc (Zn) concentrations and Zn kinetic parameters and to measure relationships of Zn status with taste acuity, food frequency, and hair Zn in humans. The subjects were 33 premenopausal women not taking oral contraceptives and dietary supplements containing iron and Zn. Main outcomes were plasma Zn concentrations, Zn kinetic parameters based on the three-compartment mammillary model using 67Zn as a tracer, electrical taste detection thresholds, and food frequencies. Lower plasma Zn was significantly ( P < 0.01) associated with smaller sizes of the central and the lesser peripheral Zn pools, faster disappearance of tracer from plasma, and higher transfer rate constants from the lesser peripheral pool to the central pool and from the central pool to the greater peripheral pool. The break points in the plasma Zn-Zn kinetics relationship were found between 9.94 and 11.5 μmol/l plasma Zn. Smaller size of the lesser peripheral pool was associated with lower frequency of beef consumption and higher frequency of bran breakfast cereal consumption. Hypozincemic women with plasma Zn <10.7 μmol/l or 700 ng/ml had decreased thresholds of electrical stimulation for gustatory nerves. Our results based on Zn kinetics support the conventional cutoff value of plasma Zn (10.7 μmol/l or 700 ng/ml) between normal and low Zn status.

A Six‐Compartment Linear Mammillary Model

Kybernetes ◽  
1992 ◽  
Vol 21 (1) ◽  
pp. 23-29
Author(s):  
Y. Cherruault ◽  
V.B. Sarin
Keyword(s):  
Mammillary Model

scholarly journals Association between zinc pool sizes and iron stores in premenopausal women without anaemia

2007 ◽  
Vol 98 (6) ◽  
pp. 1214-1223 ◽  
Author(s):  
Katsuhiko Yokoi ◽  
Harold H. Sandstead ◽  
Norman G. Egger ◽  
Nancy W. Alcock ◽  
V. M. Sadagopa Ramanujam ◽  
...  
Keyword(s):  
Premenopausal Women ◽  
Simultaneous Occurrence ◽  
Zn Deficiency ◽  
Contributing Factors ◽  
Highly Correlated ◽  
Zn Status ◽  
The Relationship ◽  
Pool Sizes ◽  
Mammillary Model ◽  
Apparently Healthy

The simultaneous occurrence of Zn and Fe deficiencies in man has been known since the discovery of human Zn deficiency. However, it is not established that low Fe storesper seor Fe-deficiency anaemia infer low Zn status. Therefore our objective was to identify relationships between Zn and Fe status in premenopausal women without anaemia. We also examined the contribution of food frequencies and blood loss to Zn and Fe status. The subjects were thirty-three apparently healthy premenopausal women without anaemia, who were not taking dietary supplements containing Zn or Fe or oral contraceptives. Main outcomes were Zn kinetic parameters based on the three-compartment mammillary model and serum ferritin (SF) concentration; contributing factors were the frequency of consumption of specific foods and menorrhagia. Lower SF was significantly associated with smaller sizes of Zn pools. The breakpoint in the relationship between SF and the lesser peripheral Zn pool was found to be 21·0 μg SF/l. SF also correlated positively with frequency of beef consumption and negatively with bleeding through menstrual pads (BTMP). Similar to SF, the Zn pool sizes correlated positively with frequency of beef consumption, and negatively with BTMP. In summary, Zn pool sizes and Fe stores were highly correlated in premenopausal women. SF concentrations < 20 μg/l suggest an increased likelihood of low Zn status.

Sign in / Sign up

Export Citation Format

Share Document