Subclinical effects of groundwater contaminants. II. Alteration of regional brain monoamine neurotransmitters by benzene in CD-1 mice

1988 ◽  
Vol 17 (6) ◽  
pp. 799-805 ◽  
Author(s):  
Gin C. Hsieh ◽  
Robert D. R. Parker ◽  
Raghubir P. Sharma
Keyword(s):  
Monoamine Neurotransmitters ◽  
Groundwater Contaminants ◽  
Regional Brain ◽  
Brain Monoamine

scholarly journals Tyrosine Uptake and Regional Brain Monoamine Metabolites in a Rat Model Resembling Congenital Hyperammonemia

1996 ◽  
Vol 39 (6) ◽  
pp. 1036-1040 ◽  
Author(s):  
Jean-Pierre Colombo ◽  
Claude Bachmann ◽  
Heidi Cervantes ◽  
Milica Kokorovic ◽  
Rachel Perritaz
Keyword(s):  
Rat Model ◽  
Monoamine Metabolites ◽  
Regional Brain ◽  
Tyrosine Uptake ◽  
Brain Monoamine

Caffeine and regional brain monoamine utilization in mice

Life Sciences ◽  
1989 ◽  
Vol 45 (26) ◽  
pp. 2637-2644 ◽  
Author(s):  
M.G. Hadfield ◽  
C. Milio
Keyword(s):  
Regional Brain ◽  
Brain Monoamine

Effects of chronic treatment of rats with "designer" amphetamines on brain regional monoamines

1991 ◽  
Vol 69 (12) ◽  
pp. 1825-1832 ◽  
Author(s):  
Mathew T. Martin-Iverson ◽  
Bruce A. Lodge
Keyword(s):  
Chronic Treatment ◽  
Designer Drug ◽  
Olfactory Tubercle ◽  
Monoamine Neurotransmitters ◽  
Monoamine Oxidase Inhibition ◽  
Drug Levels ◽  
Regional Brain ◽  
Neurotoxic Effects ◽  
Oxidase Inhibition ◽  
Acid Metabolites

(+)-Amphetamine and two structurally related analogues, 4-methoxyamphetamine and a recent "designer drug," 4-ethoxy-amphetamine, were given to rats via subcutaneous osmotic minipumps for 1–14 days. Regional brain levels of the drugs as well as monoamine neurotransmitters and some of their major acidic metabolites were determined. Amphetamine produced depletions of dopamine in the striatum after at least 3 days of treatment but not in the nucleus accumbens or olfactory tubercle, even after 14 days of treatment. In contrast, the two ring-substituted amphetamine analogues increased levels of the monoamines and decreased levels of their acid metabolites. These data indicate that the two ring-substituted amphetamine analogues, at least one of which is a potent hallucinogen, have potent monoamine oxidase inhibition properties that are sustained during chronic treatment. Furthermore, these two compounds do not share amphetamine's regionally selective neurotoxic effects on dopamine-releasing terminals, even though brain and striatal drug levels are the same or higher than those of amphetamine.Key words: (+)-amphetamine, 4-methoxyamphetamine, 4-ethoxyamphetamine, designer amphetamines, monoamines, rats, chronic treatment.

Regional brain monoamine levels and utilization in middle-aged rats

Life Sciences ◽  
1990 ◽  
Vol 46 (4) ◽  
pp. 295-299 ◽  
Author(s):  
M.G. Hadfield ◽  
C. Milio
Keyword(s):  
Aged Rats ◽  
Middle Aged ◽  
Regional Brain ◽  
Brain Monoamine
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