A preliminary study of the pharmacodynamics and pharmacokinetics of a novel enkephalin analogue [Tyr-D.Arg-Gly-Phe(4NO2)�Pro�NH2 (BW443C)] in healthy volunteers

1988 ◽  
Vol 34 (1) ◽  
pp. 67-71 ◽  
Author(s):  
J. Posner ◽  
K. Dean ◽  
S. Jeal ◽  
S. G. Moody ◽  
A. W. Peck ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Preliminary Study

scholarly journals Lingual–Alveolar Contact Pressure During Speech in Amyotrophic Lateral Sclerosis: Preliminary Findings

2017 ◽  
Vol 60 (4) ◽  
pp. 810-825 ◽  
Author(s):  
Jeff Searl ◽  
Stephanie Knollhoff ◽  
Richard J. Barohn
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Healthy Volunteers ◽  
Contact Pressure ◽  
Statistical Difference ◽  
Healthy Controls ◽  
Perceptual Judgments ◽  
Before And After ◽  
Preliminary Study ◽  
Contact Pressures ◽  
Lateral Sclerosis

Purpose This preliminary study on lingual–alveolar contact pressures (LACP) in people with amyotrophic lateral sclerosis (ALS) had several aims: (a) to evaluate whether the protocol induced fatigue, (b) to compare LACP during speech (LACP-Sp) and during maximum isometric pressing (LACP-Max) in people with ALS (PALS) versus healthy controls, (c) to compare the percentage of LACP-Max utilized during speech (%Max) for PALS versus controls, and (d) to evaluate relationships between LACP-Sp and LACP-Max with word intelligibility. Method Thirteen PALS and 12 healthy volunteers produced /t, d, s, z, l, n/ sounds while LACP-Sp was recorded. LACP-Max was obtained before and after the speech protocol. Word intelligibility was obtained from auditory–perceptual judgments. Results LACP-Max values measured before and after completion of the speech protocol did not differ. LACP-Sp and LACP-Max were statistically lower in the ALS bulbar group compared with controls and PALS with only spinal symptoms. There was no statistical difference between groups for %Max. LACP-Sp and LACP-Max were correlated with word intelligibility. Conclusions It was feasible to obtain LACP-Sp measures without inducing fatigue. Reductions in LACP-Sp and LACP-Max for bulbar speakers might reflect tongue weakness. Although confirmation of results is needed, the data indicate that individuals with high word intelligibility maintained LACP-Sp at or above 2 kPa and LACP-Max at or above 50 kPa.

Acute anti-hyperglycaemic effects of an unripe apple preparation containing phlorizin in healthy volunteers: a preliminary study

2014 ◽  
Vol 95 (3) ◽  
pp. 560-568 ◽  
Author(s):  
Elina Makarova ◽  
Paweł Górnaś ◽  
Ilze Konrade ◽  
Dace Tirzite ◽  
Helena Cirule ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Preliminary Study

scholarly journals Targeted and Untargeted Metabolomics to Explore the Bioavailability of the Secoiridoids from a Seed/Fruit Extract (Fraxinus angustifolia Vahl) in Human Healthy Volunteers: A Preliminary Study

Molecules ◽  
2015 ◽  
Vol 20 (12) ◽  
pp. 22202-22219 ◽  
Author(s):  
Rocío García-Villalba ◽  
Francisco Tomás-Barberán ◽  
Pascale Fança-Berthon ◽  
Marc Roller ◽  
Pilar Zafrilla ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Untargeted Metabolomics ◽  
Fruit Extract ◽  
Fraxinus Angustifolia ◽  
Preliminary Study

A preliminary study of the effects of m-CPP on sleep architecture and behavior in healthy volunteers

1989 ◽  
Vol 25 (7) ◽  
pp. A52
Author(s):  
B.A. Lawlor ◽  
P.A. Newhouse ◽  
T. Balkin ◽  
S.E. Molchan ◽  
A.M. Mellow ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Sleep Architecture ◽  
Preliminary Study ◽  
And Behavior

Hemodynamic effects of positive end-expiratory pressure during abdominal hyperpression: A preliminary study in healthy volunteers

2012 ◽  
Vol 27 (1) ◽  
pp. 33-36 ◽  
Author(s):  
Jean-Luc Fellahi ◽  
Vincent Caille ◽  
Cyril Charron ◽  
Georges Daccache ◽  
Antoine Vieillard-Baron
Keyword(s):  
Healthy Volunteers ◽  
Hemodynamic Effects ◽  
Positive End Expiratory Pressure ◽  
Preliminary Study
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