Assessing drug exposure in rodent toxicity studies without satellite animals

1993 ◽  
Vol 21 (3) ◽  
pp. 323-334 ◽  
Author(s):  
Jerry R. Nedelman ◽  
Ekaterina Gibiansky ◽  
Francis L. S. Tse ◽  
Christine Babiuk
Keyword(s):  
Drug Exposure ◽  
Toxicity Studies

Eisai Hyperbilirubinemic Rat (EHBR) as an Animal Model Affording High Drug-Exposure in Toxicity Studies on Organic Anions

2004 ◽  
Vol 19 (5) ◽  
pp. 339-351 ◽  
Author(s):  
Hiroyasu Naba ◽  
Chitose Kuwayama ◽  
Chihaya Kakinuma ◽  
Shuhei Ohnishi ◽  
Takuo Ogihara
Keyword(s):  
Animal Model ◽  
Drug Exposure ◽  
Organic Anions ◽  
High Drug ◽  
Toxicity Studies ◽  
Eisai Hyperbilirubinemic Rat

Preclinical Toxicity Studies of Naltrexone

1976 ◽  
Author(s):  
Monique C. Braude ◽  
J. Michael Morrison
Keyword(s):  
Toxicity Studies

Psychogenic Mass Syndrome in Anti-Cancer Drug Exposure

2010 ◽  
Author(s):  
N. Magnavita ◽  
I. lavicoli ◽  
V. Leso ◽  
A. Bergamaschi
Keyword(s):  
Drug Exposure ◽  
Cancer Drug ◽  
Anti Cancer

Hair Testing and Maternal Drug Exposure

2005 ◽  
Vol 35 (18) ◽  
pp. 45
Author(s):  
GIDEON KOREN
Keyword(s):  
Drug Exposure ◽  
Hair Testing

Human liver cell cultivation for long-term in vitro toxicity studies in a miniaturized multi-compartment 3D bioreactor system

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
SA Hoffmann ◽  
M Lübberstedt ◽  
U Müller-Vieira ◽  
D Knobeloch ◽  
A Nüssler ◽  
...  
Keyword(s):  
Liver Cell ◽  
Human Liver ◽  
In Vitro Toxicity ◽  
Cell Cultivation ◽  
Toxicity Studies ◽  
Human Liver Cell ◽  
Bioreactor System

Acute and chronic toxicity studies on Polygonum glabrum in experimental animals

2020 ◽  
Vol 3 (1) ◽  
pp. 7-10
Author(s):  
Saravanakumar A ◽  
Gandhimathi R
Keyword(s):  
Chronic Toxicity ◽  
Clinical Stage ◽  
Herbal Medicines ◽  
Plant Roots ◽  
Root Extract ◽  
Experimental Animals ◽  
Toxicity Studies ◽  
Acute And Chronic Toxicity ◽  
Diuretic Agents

Polygonum glabrum is being used in traditional and folklore medicine to treat pneumonia and jaundice. Plant roots are used in ayurvedic preparations to treat fever and colic. The leaves are used as diuretic agents and process vermifuge action. Plant decoction is also used in the treatment of Rheumatism. Besides having many uses and folklore claims, herbal medicines are to be thoroughly investigated for their toxicity also. Therefore this work is being carried out to examine the toxicity of the drug and established dose is safe to use in the clinical stage. The current research studied the acute and chronic toxicity of Polygonum glabrum root extract in rats. It is proved that there was no change in any parameter tested both in acute and chronic toxicity, which means the extract is safe and non-toxic at the dose of 2g/kg also.

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