Convergence of impulses on anterior hypothalamic neurons during local temperature stimulation of the skin

1982 ◽  
Vol 13 (4) ◽  
pp. 273-277
Author(s):  
E. Khalilov ◽  
L. P. Dymnikova
Keyword(s):  
Local Temperature ◽  
Hypothalamic Neurons ◽  
Temperature Stimulation ◽  
Stimulation Of

Cortical unit responses to temperature stimulation of the skin

1971 ◽  
Vol 25 (1) ◽  
pp. 184-187 ◽  
Author(s):  
Norman R. Kreisman ◽  
Irwin D. Zimmerman
Keyword(s):  
Cortical Unit ◽  
Temperature Stimulation ◽  
Stimulation Of

scholarly journals Neuropeptide VF neurons promote sleep via the serotonergic raphe

2019 ◽  
Author(s):  
Daniel A. Lee ◽  
Grigorios Oikonomou ◽  
Tasha Cammidge ◽  
Young Hong ◽  
David A. Prober
Keyword(s):  
Calcium Imaging ◽  
Neural Circuit ◽  
Raphe Nuclei ◽  
Hypothalamic Neurons ◽  
Optogenetic Stimulation ◽  
Genetic Epistasis ◽  
Normal Sleep ◽  
Genetic Labeling ◽  
Raphé Nuclei ◽  
Stimulation Of

ABSTRACTAlthough several sleep-regulating neurons have been identified, little is known about how they interact with each other for sleep/wake control. We previously identified neuropeptide VF (NPVF) and the hypothalamic neurons that produce it as a sleep-promoting system (Lee et al., 2017). Here we use zebrafish to describe a neural circuit in which neuropeptide VF (npvf)-expressing neurons control sleep via the serotonergic raphe nuclei (RN), a hindbrain structure that promotes sleep in both diurnal zebrafish and nocturnal mice. Using genetic labeling and calcium imaging, we show that npvf-expressing neurons innervate and activate serotonergic RN neurons. We additionally demonstrate that optogenetic stimulation of npvf-expressing neurons induces sleep in a manner that requires NPVF and is abolished when the RN are ablated or lack serotonin. Finally, genetic epistasis demonstrates that NPVF acts upstream of serotonin in the RN to maintain normal sleep levels. These findings reveal a novel hypothalamic-hindbrain circuit for sleep/wake control.

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