Ryanodine inhibits calcium transients evoked by action potentials in a subpopulation of rat dorsal root ganglion neurons

1994 ◽  
Vol 26 (6) ◽  
pp. 344-346
Author(s):  
A. Shmigol'
Keyword(s):  
Dorsal Root Ganglion ◽  
Action Potentials ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
Calcium Transients ◽  
Ganglion Neurons

The Effects of pH on Beta-Endorphin and Morphine Inhibition of Calcium Transients in Dorsal Root Ganglion Neurons

2006 ◽  
Vol 7 (7) ◽  
pp. 488-499 ◽  
Author(s):  
Irina Vetter ◽  
Daniel Kapitzke ◽  
Siobhan Hermanussen ◽  
Gregory Raymond Monteith ◽  
Peter John Cabot
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
Calcium Transients ◽  
Beta Endorphin ◽  
Effects Of Ph ◽  
Ganglion Neurons

Variation in IH, IIR, and ILEAK between acutely isolated adult rat dorsal root ganglion neurons of different size

1994 ◽  
Vol 71 (1) ◽  
pp. 271-279 ◽  
Author(s):  
R. S. Scroggs ◽  
S. M. Todorovic ◽  
E. G. Anderson ◽  
A. P. Fox
Keyword(s):  
Dorsal Root Ganglion ◽  
Action Potentials ◽  
Dorsal Root ◽  
Membrane Surface ◽  
Small Diameter ◽  
Reversal Potential ◽  
Dorsal Root Ganglion Neurons ◽  
Time Dependent ◽  
Drg Neurons ◽  
Ganglion Neurons

1. The distribution of IH, IIR, and ILEAK was studied in different diameter rat dorsal root ganglion (DRG) neuron cell bodies (neurons). DRG neurons were studied in three diameter ranges: small (19–27 microns), medium (33–37 microns), and large (44-54 microns). IH was defined as a slowly activating inward current evoked by hyperpolarizing voltage steps from a holding potential (HP) of -60 mV, and blocked by 1 mM Cs2+ but not 1 mM Ba2+. Inward rectifier current (IIR) was defined as a rapidly activating current evoked by hyperpolarizations from HP -60 mV, which rectified inwardly around the reversal potential for potassium (EK), and was completely blocked by 100 microM Ba2+. ILEAK was defined as an outward resting current at HP -60 mV, which did not rectify and was blocked by 100 microM Ba2+ but not by 2 mM Cs+. 2. IH was observed in 23 of 23 large, 11 of 12 medium, and in 9 of 20 small diameter DRG neurons tested. Peak IH normalized to membrane surface area was significantly greater in large than in medium or small diameter DRG neurons expressing IH. All neurons exhibiting IH under voltage clamp conditions had short duration action potentials and exhibited time-dependent rectification under current clamp conditions, properties similar to A-type DRG neurons. The 11 small diameter neurons not expressing IH had long duration action potentials and did not exhibit time-dependent rectification, properties similar to C-type DRG neurons. 3. IIR was detected in 18 of 22 medium diameter neurons tested.(ABSTRACT TRUNCATED AT 250 WORDS)

Interaction of opioids and membrane potential to modulate Ca2+ channels in rat dorsal root ganglion neurons

1995 ◽  
Vol 73 (5) ◽  
pp. 1793-1798 ◽  
Author(s):  
M. D. Womack ◽  
E. W. McCleskey
Keyword(s):  
Dorsal Root Ganglion ◽  
Sensory Neurons ◽  
Action Potentials ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
High Threshold ◽  
Partial Recovery ◽  
Drg Neurons ◽  
Ganglion Neurons ◽  
Ca2 Channels

1. Using patch-clamp methods, we show that brief prepulses to very positive voltages increase (facilitate) the amplitude of current through Ca2+ channels during a subsequent test pulse in some, but not all, dorsal root ganglion (DRG) sensory neurons. The amplitude of this facilitated current generally increases when the Ca2+ channels are inhibited by activation of the mu-opioid receptor. 2. The facilitated current is blocked by omega-conotoxin GVIA, activates in the range of high-threshold Ca2+ channels, and inactivates at relatively negative holding voltages. Thus facilitated current passes through N-type Ca2+ channels, the same channels that are inhibited by opioids and control neurotransmitter release in sensory neurons. 3. Although maximal facilitation occurs only at unphysiologically high membrane potentials (above +100 mV), some facilitation is seen after prepulses to voltages reached during action potentials. After return to the holding potential, facilitation persists for hundreds of milliseconds, considerably longer than in other neurons. Brief trains of pulses designed to mimic action potentials caused small facilitation (19% of maximal) in a fraction (8 of 24) of opioid-inhibited neurons. 4. We conclude that 1) prepulses to extremely positive voltages can cause partial recovery of Ca2+ channels inhibited by opioids; and 2) small, but detectable, facilitation is also seen after physiological stimulation in some DRG neurons. Facilitation, largely considered a biophysical epiphenomenon because of the extreme voltages used to induce it, appears to be physiologically relevant during opioid inhibition of Ca2+ channels in DRG neurons.

Block of Na+ currents and suppression of action potentials in embryonic rat dorsal root ganglion neurons by ranolazine

2012 ◽  
Vol 62 (7) ◽  
pp. 2251-2260 ◽  
Author(s):  
Ryoko Hirakawa ◽  
Nesrine El-Bizri ◽  
John C. Shryock ◽  
Luiz Belardinelli ◽  
Sridharan Rajamani
Keyword(s):  
Dorsal Root Ganglion ◽  
Action Potentials ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
Na Currents ◽  
Ganglion Neurons

scholarly journals Reply to “TRPA1-dependent calcium transients and CGRP release in DRG neurons require extracellular calcium”

2020 ◽  
Vol 219 (6) ◽  
Author(s):  
Bing Liu ◽  
Muhammad Younus ◽  
Suhua Sun ◽  
Yiman Li ◽  
Yuan Wang ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Intracellular Calcium ◽  
Dorsal Root ◽  
Extracellular Calcium ◽  
Dorsal Root Ganglion Neurons ◽  
Calcium Transients ◽  
Drg Neurons ◽  
Cgrp Release ◽  
Ganglion Neurons

In this issue, Gebhardt et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.201702151) express interest in our recently published work (Shang et al. 2016. J. Cell Biol.https://doi.org/10.1083/jcb.201603081). Here, we would like to address their concerns regarding the lysosomal TRPA1-mediated intracellular calcium transients in dorsal root ganglion neurons.

Differential action potentials and firing patterns in injured and uninjured small dorsal root ganglion neurons after nerve injury

2004 ◽  
Vol 1009 (1-2) ◽  
pp. 147-158 ◽  
Author(s):  
Xu-Feng Zhang ◽  
Chang Z Zhu ◽  
Rama Thimmapaya ◽  
Won S Choi ◽  
Prisca Honore ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Nerve Injury ◽  
Action Potentials ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
Firing Patterns ◽  
Ganglion Neurons ◽  
Differential Action

scholarly journals Millisecond infrared laser pulses depolarize and elicit action potentials on in-vitro dorsal root ganglion neurons

2017 ◽  
Vol 8 (10) ◽  
pp. 4568 ◽  
Author(s):  
Lambert Paris ◽  
Isabelle Marc ◽  
Benoit Charlot ◽  
Michel Dumas ◽  
Jean Valmier ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Action Potentials ◽  
Dorsal Root ◽  
Laser Pulses ◽  
Infrared Laser ◽  
Dorsal Root Ganglion Neurons ◽  
Ganglion Neurons
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