Enzymes in preparative organic synthesis. Chemical equilibrium in countercurrent biphasic water-organic systems

1989 ◽  
Vol 11 (12) ◽  
pp. 875-880 ◽  
Author(s):  
A. N. Semenov ◽  
A. P. Gachok ◽  
M. I. Titov ◽  
K. Martinek
Keyword(s):  
Organic Synthesis ◽  
Chemical Equilibrium ◽  
Organic Systems

Enzymes in preparative organic synthesis: The problem of increasing the yield of product

1988 ◽  
Vol 53 (12) ◽  
pp. 2963-2985 ◽  
Author(s):  
Anatolii N. Semenov ◽  
Václav Čeřovský ◽  
Mikhail I. Titov ◽  
Karel Martinek
Keyword(s):  
Organic Solvent ◽  
Organic Synthesis ◽  
Chemical Equilibrium ◽  
Partition Coefficients ◽  
Volume Ratio ◽  
Aqueous Biphasic Systems ◽  
Micellar Systems ◽  
Aqueous Biphasic ◽  
Biphasic Systems ◽  
Hydroxy Groups

Approaches and methods increasing yield of the desired products in enzymatically catalyzed thermodynamically unfavourable syntheses are reviewed. Attention is paid especially to reactions in biphasic systems (water-water-immiscible organic solvent) and their modifications (micellar systems, pseudo-biphasic systems, aqueous biphasic systems, etc.). The dependence of chemical equilibrium and conversion of enzymatically catalyzed processes on the volume ratio of organic and aqueous phases and on the partition coefficients is described. Enzymatically catalyzed syntheses of peptides, amides, esters, NAD-dependent oxidations of hydroxy groups, etc. are given as examples. Various approaches to enzymatically catalyzed processes and their prospects are discussed.

Lithiated γ-Tosyl-Substituted Benzylmethallylamine:  New γ-Amino Methallyl Sulfone Anions in Organic Synthesis

1997 ◽  
Vol 62 (5) ◽  
pp. 1564-1564
Author(s):  
Diego A. Alonso ◽  
Larry R. Falvello ◽  
Balbino Mancheño ◽  
Carmen Nájera ◽  
Milagros Tomás
Keyword(s):  
Organic Synthesis
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