Identification and characterization of the ATP�Mg-dependent protein phosphatase activator (F A) as a microtubule protein kinase in the brain

1991 ◽  
Vol 10 (2) ◽  
pp. 171-181 ◽  
Author(s):  
Shiaw-Der Yang ◽  
Jau-Song Yu ◽  
Yein-Gei Lai
Keyword(s):  
Protein Kinase ◽  
Protein Phosphatase ◽  
Microtubule Protein ◽  
Dependent Protein ◽  
The Brain ◽  
Identification And Characterization

scholarly journals Calcineurin, a Calcium/Calmodulin-dependent Protein Phosphatase, Is Involved in Movement, Fertility, Egg Laying, and Growth inCaenorhabditis elegans

2002 ◽  
Vol 13 (9) ◽  
pp. 3281-3293 ◽  
Author(s):  
Jaya Bandyopadhyay ◽  
Jiyeon Lee ◽  
Jungsoo Lee ◽  
Jin Il Lee ◽  
Jae-Ran Yu ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Protein Phosphatase ◽  
Body Wall ◽  
Egg Laying ◽  
Α Subunit ◽  
C Elegans ◽  
Calcium Calmodulin Dependent ◽  
Dependent Protein ◽  
Identification And Characterization

Calcineurin is a Ca2+-calmodulin–dependent serine/threonine protein phosphatase that has been implicated in various signaling pathways. Here we report the identification and characterization of calcineurin genes in Caenorhabditis elegans (cna-1 and cnb-1), which share high homology with Drosophila and mammalian calcineurin genes. C. elegans calcineurin binds calcium and functions as a heterodimeric protein phosphatase establishing its biochemical conservation in the nematode. Calcineurin is expressed in hypodermal seam cells, body-wall muscle, vulva muscle, neuronal cells, and in sperm and the spermatheca. cnb-1 mutants showed pleiotropic defects including lethargic movement and delayed egg-laying. Interestingly, these characteristic defects resembled phenotypes observed in gain-of-function mutants ofunc-43/Ca2+-calmodulin–dependent protein kinase II (CaMKII) and goa-1/Go-protein α-subunit. Double mutants of cnb-1 andunc-43(gf) displayed an apparent synergistic severity of movement and egg-laying defects, suggesting that calcineurin may have an antagonistic role in CaMKII-regulated phosphorylation signaling pathways in C. elegans.

Identification and Characterization of CaMKP-N, Nuclear Calmodulin-Dependent Protein Kinase Phosphatase

2001 ◽  
Vol 130 (6) ◽  
pp. 833-840 ◽  
Author(s):  
M. Takeuchi ◽  
A. Ishida ◽  
I. Kameshita ◽  
T. Kitani ◽  
S. Okuno ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Dependent Protein Kinase ◽  
Dependent Protein ◽  
Identification And Characterization

scholarly journals Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells

FEBS Letters ◽  
2003 ◽  
Vol 550 (1-3) ◽  
pp. 57-63 ◽  
Author(s):  
Yumi Ishikawa ◽  
Hiroshi Tokumitsu ◽  
Hiroyuki Inuzuka ◽  
Maki Murata-Hori ◽  
Hiroshi Hosoya ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Hela Cells ◽  
Dependent Protein Kinase ◽  
Kinase Cascade ◽  
Dependent Protein ◽  
Identification And Characterization ◽  
Protein Kinase Cascade
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