Enantioselective hydrolysis of hydrophobic amino acid derivatives by lipases

1992 ◽  
Vol 14 (6) ◽  
pp. 461-464 ◽  
Author(s):  
Aih-Jing Chiou ◽  
Shih-Hsiung Wu ◽  
Kung-Tsung Wang
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Enantioselective Hydrolysis ◽  
Hydrophobic Amino Acid ◽  
Hydrolysis Of

scholarly journals Novel Amino Acid Derivatives of Quinolines as Potential Antibacterial and Fluorophore Agents

2020 ◽  
Vol 88 (4) ◽  
pp. 57
Author(s):  
Oussama Moussaoui ◽  
Rajendra Bhadane ◽  
Riham Sghyar ◽  
El Mestafa El Hadrami ◽  
Soukaina El Amrani ◽  
...  
Keyword(s):  
Amino Acid ◽  
Methyl Esters ◽  
Amino Acid Derivatives ◽  
Bacterial Strains ◽  
Fluorescent Properties ◽  
Topoisomerase Iv ◽  
Microdilution Method ◽  
Hydrolysis Of ◽  
Derivatives Of

A new series of amino acid derivatives of quinolines was synthesized through the hydrolysis of amino acid methyl esters of quinoline carboxamides with alkali hydroxide. The compounds were purified on silica gel by column chromatography and further characterized by TLC, NMR and ESI-TOF mass spectrometry. All compounds were screened for in vitro antimicrobial activity against different bacterial strains using the microdilution method. Most of the synthesized amino acid-quinolines show more potent or equipotent inhibitory action against the tested bacteria than their correspond esters. In addition, many of them exhibit fluorescent properties and could possibly be utilized as fluorophores. Molecular docking and simulation studies of the compounds at putative bacterial target enzymes suggest that the antimicrobial potency of these synthesized analogues could be due to enzyme inhibition via their favorable binding at the fluoroquinolone binding site at the GyrA subunit of DNA gyrase and/or the ParC subunit of topoisomerase-IV.

ChemInform Abstract: Perfect Enantioselective Hydrolysis of Amino Acid Esters by Modified . alpha.-Chymotrypsin.

ChemInform ◽  
2010 ◽  
Vol 26 (21) ◽  
pp. no-no
Author(s):  
R. UEOKA ◽  
J. OKAI ◽  
K. SHIMADA ◽  
D. SEGAWA ◽  
T. NAKATA ◽  
...  
Keyword(s):  
Amino Acid ◽  
Enantioselective Hydrolysis ◽  
Amino Acid Esters ◽  
Hydrolysis Of ◽  
Acid Esters

scholarly journals Remarkably Enhanced Enantioselective Hydrolysis of Amino Acid Esters With Tripeptide Catalyst in Micellar Systems.

1995 ◽  
pp. 351-357 ◽  
Author(s):  
Koichi GOTO ◽  
Jiro OKAI ◽  
Yumiko EJIMA ◽  
Takatoshi ITO ◽  
Hideo OKAI ◽  
...  
Keyword(s):  
Amino Acid ◽  
Enantioselective Hydrolysis ◽  
Amino Acid Esters ◽  
Micellar Systems ◽  
Hydrolysis Of ◽  
Acid Esters

scholarly journals Enantioselective hydrolysis of amino acid esters in organized hybrid assemblies.

1989 ◽  
pp. 181-185 ◽  
Author(s):  
Ryuichi UEOKA ◽  
Yoko MATSUMOTO ◽  
Naruto MATSUO ◽  
Takahiro TAGUCHI ◽  
Shinji UBATA
Keyword(s):  
Amino Acid ◽  
Enantioselective Hydrolysis ◽  
Amino Acid Esters ◽  
Hybrid Assemblies ◽  
Hydrolysis Of ◽  
Acid Esters

scholarly journals Steric-Control for the Enantioselective Hydrolysis of Amino Acid Esters in Hybrid Membrane Systems

2003 ◽  
Vol 51 (2) ◽  
pp. 224-226 ◽  
Author(s):  
Osamu Tanoue ◽  
Hideaki Ichihara ◽  
Koichi Goto ◽  
Yoko Matsumoto ◽  
Ryuichi Ueoka
Keyword(s):  
Amino Acid ◽  
Hybrid Membrane ◽  
Enantioselective Hydrolysis ◽  
Amino Acid Esters ◽  
Membrane Systems ◽  
Hydrolysis Of ◽  
Acid Esters ◽  
Steric Control
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