Coding of Gibbs function flows from nucleotide pools

1980 ◽  
Vol 23 (4) ◽  
pp. 483-494 ◽  
Author(s):  
Alexandr Křemen
Keyword(s):  
Gibbs Function ◽  
Nucleotide Pools

Virtual Work & d’Alembert’s Principle

2018 ◽  
Author(s):  
Peter Mann
Keyword(s):  
Euler Equations ◽  
Virtual Work ◽  
Lagrange Equation ◽  
Classical Mechanics ◽  
Rigid Bodies ◽  
Gibbs Function ◽  
Constraint Force ◽  
Appell Equations ◽  
Jourdain's Principle ◽  
D'alembert's Principle

This chapter discusses virtual work, returning to the Newtonian framework to derive the central Lagrange equation, using d’Alembert’s principle. It starts off with a discussion of generalised force, applied force and constraint force. Holonomic constraints and non-holonomic constraint equations are then investigated. The corresponding principles of Gauss (Gauss’s least constraint) and Jourdain are also documented and compared to d’Alembert’s approach before being generalised into the Mangeron–Deleanu principle. Kane’s equations are derived from Jourdain’s principle. The chapter closes with a detailed covering of the Gibbs–Appell equations as the most general equations in classical mechanics. Their reduction to Hamilton’s principle is examined and they are used to derive the Euler equations for rigid bodies. The chapter also discusses Hertz’s least curvature, the Gibbs function and Euler equations.

scholarly journals Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Joonas A. Jamsen ◽  
Akira Sassa ◽  
Lalith Perera ◽  
David D. Shock ◽  
William A. Beard ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Time Lapse ◽  
Strand Break ◽  
Structural Basis ◽  
End Joining ◽  
Strand Breaks ◽  
Nucleotide Pools ◽  
Nucleotide Insertion ◽  
Non Homologous End Joining

AbstractReactive oxygen species (ROS) oxidize cellular nucleotide pools and cause double strand breaks (DSBs). Non-homologous end-joining (NHEJ) attaches broken chromosomal ends together in mammalian cells. Ribonucleotide insertion by DNA polymerase (pol) μ prepares breaks for end-joining and this is required for successful NHEJ in vivo. We previously showed that pol μ lacks discrimination against oxidized dGTP (8-oxo-dGTP), that can lead to mutagenesis, cancer, aging and human disease. Here we reveal the structural basis for proficient oxidized ribonucleotide (8-oxo-rGTP) incorporation during DSB repair by pol μ. Time-lapse crystallography snapshots of structural intermediates during nucleotide insertion along with computational simulations reveal substrate, metal and side chain dynamics, that allow oxidized ribonucleotides to escape polymerase discrimination checkpoints. Abundant nucleotide pools, combined with inefficient sanitization and repair, implicate pol μ mediated oxidized ribonucleotide insertion as an emerging source of widespread persistent mutagenesis and genomic instability.

scholarly journals Limited nucleotide pools restrict Epstein–Barr virus-mediated B-cell immortalization

Oncogenesis ◽  
2017 ◽  
Vol 6 (6) ◽  
pp. e349-e349 ◽  
Author(s):  
A Y Hafez ◽  
J E Messinger ◽  
K McFadden ◽  
G Fenyofalvi ◽  
C N Shepard ◽  
...  
Keyword(s):  
B Cell ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Nucleotide Pools ◽  
Cell Immortalization ◽  
Epstein Barr

"An instructive Gibbs-function problem" revisited

1990 ◽  
Vol 67 (5) ◽  
pp. 383
Author(s):  
R. J. Tykodi
Keyword(s):  
Gibbs Function
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