The effect of increased crypt cell proliferation on the activity and subcellular localization of esterases and alkaline phosphatase in the rat small intestine

1977 ◽  
Vol 9 (1) ◽  
pp. 61-75 ◽  
Author(s):  
J. M. Van Dongen ◽  
J. Kooyman ◽  
W. J. Visser ◽  
S. J. Holt ◽  
H. Galjaard
Keyword(s):  
Cell Proliferation ◽  
Alkaline Phosphatase ◽  
Small Intestine ◽  
Subcellular Localization ◽  
Crypt Cell ◽  
Rat Small Intestine ◽  
Crypt Cell Proliferation

scholarly journals Vitamin A Up-Regulates Expression of Bone-Type Alkaline Phosphatase in Rat Small Intestinal Crypt Cell Line and Fetal Rat Small Intestine

1998 ◽  
Vol 128 (11) ◽  
pp. 1869-1877 ◽  
Author(s):  
Takeshi Nikawa ◽  
Kazuhito Rokutan ◽  
Kayo Nanba ◽  
Kaori Tokuoka ◽  
Shigetada Teshima ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Small Intestine ◽  
Vitamin A ◽  
Cell Line ◽  
Crypt Cell ◽  
Rat Small Intestine ◽  
Intestinal Crypt ◽  
Fetal Rat ◽  
Small Intestinal ◽  
Intestinal Crypt Cell

scholarly journals The Effect of Ischemic Villus Cell Damage on Crypt Cell Proliferation in the Small Intestine

1976 ◽  
Vol 71 (5) ◽  
pp. 786-792 ◽  
Author(s):  
R.P.C. Rijke ◽  
W.R. Hanson ◽  
H.M. Plaisier ◽  
J.W. Osborne
Keyword(s):  
Cell Proliferation ◽  
Small Intestine ◽  
Cell Damage ◽  
Crypt Cell ◽  
Crypt Cell Proliferation ◽  
Villus Cell

scholarly journals Spdef deletion rescues the crypt cell proliferation defect in conditional Gata6 null mouse small intestine

2014 ◽  
Vol 15 (1) ◽  
pp. 3 ◽  
Author(s):  
Boaz E Aronson ◽  
Kelly A Stapleton ◽  
Laurens ATM Vissers ◽  
Eva Stokhuijzen ◽  
Hanneke Bruijnzeel ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Small Intestine ◽  
Crypt Cell ◽  
Null Mouse ◽  
Crypt Cell Proliferation ◽  
Mouse Small Intestine

A growth-stimulating activity derived from the proximal small intestine is associated with an adaptive response

1990 ◽  
Vol 68 (5) ◽  
pp. 646-649 ◽  
Author(s):  
V. L. Grey ◽  
C. L. Morin
Keyword(s):  
Cell Proliferation ◽  
Small Intestine ◽  
Thymidine Kinase ◽  
Kinase Activity ◽  
Crypt Cell ◽  
General Mechanism ◽  
Cell Renewal ◽  
Thymidine Kinase Activity ◽  
Crypt Cell Proliferation ◽  
Proximal Intestine

Luminal nutrition is important for the maintenance of small intestinal structure and function. The equilibrium between crypt cell production and villous cell loss in the mucosal epithelium of the small intestine is altered under certain conditions such as after a small bowel resection. Immediately after resection, there is a marked increase in crypt cell proliferation giving rise to an adaptive hyperplasia in the remnant intestine and for this response luminal nutrition is a critical factor. We have previously demonstrated the presence of a growth-stimulating (GS) activity in a heat-stable acidic extract of the rat proximal intestine 24, 48, and 96 h after resection, which is coincidental with an increase in crypt cell proliferation as measured by thymidine kinase activity. Eight days after resection when the GS activity is no longer detectable, the thymidine kinase activity returns to control values. The molecular weights of the peptides associated with this GS activity are 4500 and 1500, as determined by Sephadex gel filtration. Of note is that the oral intake of food is necessary for the appearance of the GS activity postoperatively. The presence of the GS activity has also been demonstrated upon refeeding after a fast, as well as at weaning in the rat, two physiological situations known to be associated with increased proliferation in the small intestine. This GS activity in the proximal intestine first detected in the resection model may represent a general mechanism by which food controls the cell renewal pattern of the small intestine.Key words: stimulating activity, proximal intestine, adaptation.

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