Structural significance of the alkyl substituent at the C-4 of (+)-trans-verbenyl acetate in sex pheromonal activity of the American cockroach

1982 ◽  
Vol 8 (5) ◽  
pp. 883-895 ◽  
Author(s):  
Hisao Takayanagi ◽  
Chikao Nishino
Keyword(s):  
Alkyl Substituent ◽  
American Cockroach ◽  
Pheromonal Activity ◽  
Structural Significance

Design, Synthesis and Antiplasmodial Evaluation of Sulfoximine-triazole Hybrids as Potential Antimalarial Prototypes

2019 ◽  
Vol 15 (6) ◽  
pp. 685-692 ◽  
Author(s):  
Tommy F. Mabasa ◽  
Babatunde Awe ◽  
Dustin Laming ◽  
Henok H. Kinfe
Keyword(s):  
Alkyl Substituent ◽  
Antimalarial Drugs ◽  
Significant Activity ◽  
Design Synthesis ◽  
Antimalarial Agents ◽  
Falciparum Strain ◽  
Physiological Properties ◽  
Resistant Strains ◽  
Cytotoxicity Activities ◽  
Drug Resistant Strains

Background:Malaria, caused by the deadly Plasmodium falciparum strain, claims the lives of millions of people annually. The emergence of drug-resistant strains of P. falciparum to the artemisinin-based combination therapy (ACT), the last line of defense against malaria, is worrisome and urges for the development of new chemo-types with a new mode of action. In the search of new antimalarial agents, hybrids of triazoles and other known antimalarial drugs have been reported to possess better activity than either of the parent compounds administered individually. Despite their better activity, no hybrid antimalarial drugs have been developed so far.Objective:In the hope of developing new antimalarial prototypes, we propose the design, synthesis and antimalarial evaluation of novel sulfoximine-triazole hybrids owing to their interesting biological and physiological properties.Methods:The sulfoximine part of the hybrid will be synthesized via imidation of the corresponding sulfoxide. Propargylation of the NH moiety of the sulfoximine followed by copper-catalyzed click chemistry with benzyl azide was envisaged to provide the target sulfoximine-triazole hybrids.Results:Five novel sulfoximine-triazole hybrids possessing various substituents on the sulfoximine moiety have been successfully synthesized and evaluated for their antiplasmodial and cytotoxicity activities. The results revealed that the co-presence of the sulfoximine and triazole moieties along with a lipophilic alkyl substituent on the sulfur atom impart significant activity.Conclusion:Sulfoximine-triazole hybrids could be used as a prototype for the synthesis of new derivatives with better antiplasmodial activities.

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