Loss of N-methyl-d-aspartate (NMDA) receptor binding in rat hippocampal areas at the chronic stage after transient forebrain ischemia: Histological and NMDA receptor binding studies

1991 ◽  
Vol 16 (5) ◽  
pp. 519-524 ◽  
Author(s):  
N. Ogawa ◽  
K. Haba ◽  
K. Mizukawa ◽  
M. Asanuma ◽  
H. Hirata ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Receptor Binding ◽  
Forebrain Ischemia ◽  
Binding Studies ◽  
Chronic Stage ◽  
Transient Forebrain Ischemia ◽  
Nmda Receptor Binding

Effects of Long-Term Antipsychotic Treatment on NMDA Receptor Binding and Gene Expression of Subunits

2003 ◽  
Vol 28 (2) ◽  
pp. 235-241 ◽  
Author(s):  
Andrea Schmitt ◽  
Mathias Zink ◽  
Bettina Müller ◽  
Brigitte May ◽  
Anne Herb ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nmda Receptor ◽  
Receptor Binding ◽  
Antipsychotic Treatment ◽  
Nmda Receptor Binding

Distribution of NMDA receptor binding in developing mouse spinal cord

1993 ◽  
Vol 151 (2) ◽  
pp. 134-137 ◽  
Author(s):  
Denise L. Gonzalez ◽  
Jannon L. Fuchs ◽  
Michael H. Droge
Keyword(s):  
Spinal Cord ◽  
Nmda Receptor ◽  
Receptor Binding ◽  
Mouse Spinal Cord ◽  
Nmda Receptor Binding

scholarly journals Increased AMPA-sensitive quisqualate receptor binding and reduced NMDA receptor binding in epileptic human hippocampus

1991 ◽  
Vol 11 (2) ◽  
pp. 428-434 ◽  
Author(s):  
DA Hosford ◽  
BJ Crain ◽  
Z Cao ◽  
DW Bonhaus ◽  
AH Friedman ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Receptor Binding ◽  
Human Hippocampus ◽  
Nmda Receptor Binding

scholarly journals Less NMDA Receptor Binding in Dorsolateral Prefrontal Cortex and Anterior Cingulate Cortex Associated With Reported Early-Life Adversity but Not Suicide

2020 ◽  
Vol 23 (5) ◽  
pp. 311-318 ◽  
Author(s):  
Mark D Underwood ◽  
Mihran J Bakalian ◽  
Virginia L Johnson ◽  
Suham A Kassir ◽  
Steven P Ellis ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Receptor Binding ◽  
Early Life ◽  
Anterior Cingulate ◽  
Major Depression Disorder ◽  
Early Life Adversity ◽  
Mk 801 ◽  
Dorsolateral Prefrontal ◽  
Depression Disorder ◽  
Nmda Receptor Binding

Abstract Background Glutamate is an excitatory neurotransmitter binding to 3 classes of receptors, including the N-methyl, D-aspartate (NMDA) receptor. NMDA receptor binding is lower in major depression disorder and suicide. NMDA receptor blocking with ketamine can have antidepressant and anti-suicide effects. Early-life adversity (ELA) may cause glutamate-mediated excitotoxicity and is more common with major depression disorder and in suicide decedents. We sought to determine whether NMDA-receptor binding is altered with suicide and ELA. Methods A total 52 postmortem cases were organized as 13 quadruplets of suicide and non-suicide decedents matched for age, sex, and postmortem interval, with or without reported ELA (≤16 years). Tissue blocks containing dorsal prefrontal (BA8), dorsolateral prefrontal (BA9), or anterior cingulate (BA24) cortex were collected at autopsy. Psychiatrically healthy controls and suicide decedents underwent psychological autopsy to determine psychiatric diagnoses and details of childhood adversity. NMDA receptor binding was determined by quantitative autoradiography of [3H]MK-801 binding (displaced by unlabeled MK-801) in 20-µm-thick sections. Results [3H]MK-801 binding was not associated with suicide in BA8, BA9, or BA24. However, [3H]MK-801 binding with ELA was less in BA8, BA9, and BA24 independent of suicide (P < .05). [3H]MK-801 binding was not associated with age or postmortem interval in any brain region or group. Conclusions Less NMDA receptor binding with ELA is consistent with the hypothesis that stress can cause excitotoxicity via excessive glutamate, causing either NMDA receptor downregulation or less receptor binding due to neuron loss consequent to the excitotoxicity.

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