Persistent fetal circulation: An evolving clinical and radiographic concept of pulmonary hypertension of the newborn

1977 ◽  
Vol 6 (2) ◽  
pp. 74-80 ◽  
Author(s):  
D. F. Merten ◽  
B. W. Goetzman ◽  
R. P. Wennberg
Keyword(s):  
Pulmonary Hypertension ◽  
Fetal Circulation ◽  
Persistent Fetal Circulation

Persistent Pulmonary Hypertension of the Newborn

1991 ◽  
Vol 7 (S1) ◽  
pp. 66-69
Author(s):  
George Lister
Keyword(s):  
Pulmonary Hypertension ◽  
Diaphragmatic Hernia ◽  
Vascular Development ◽  
Clinical Syndrome ◽  
Persistent Pulmonary Hypertension ◽  
Maternal Infection ◽  
Fetal Circulation ◽  
Cns Disease ◽  
Persistent Fetal Circulation

Persistent pulmonary hypertension of the newborn or persistent fetal circulation is a clinical syndrome that is usually apparent within the first 2 days after birth because of the presence of hypoxemia (2;12;19). The syndrome was first described in an abstract by Gersony, Due, and Sinclair (6) in 1969. Two infants were reported who had “RV decompensation, cyanosis and clear lung fields… in the absence of recognizable cardiac, pulmonary, hematologic or CNS disease.” The syndrome has been associated with aspiration of meconium, diaphragmatic hernia, asphyxia, hemorrhage, shock, and maternal infection (4;18). In other cases, there is no clear antecedent event. Despite considerable interest in the problem and a wealth of research related to pulmonary vasoregulation and vascular development in the fetus and newborn, the etiology of the syndrome remains obscure 20 years since its recognition.

Pulmonary Hypertension and Persistent Fetal Circulation in the Newborn

1988 ◽  
Vol 15 (2) ◽  
pp. 389-413 ◽  
Author(s):  
Alan R. Spitzer ◽  
Jonathan Davis ◽  
William T. Clarke ◽  
Judy Bernhaum ◽  
William W. Fox
Keyword(s):  
Pulmonary Hypertension ◽  
Fetal Circulation ◽  
Persistent Fetal Circulation

Letters to the Editor

PEDIATRICS ◽  
1980 ◽  
Vol 66 (6) ◽  
pp. 1029-1029
Author(s):  
John W. Scanlon
Keyword(s):  
Pulmonary Hypertension ◽  
Case Report ◽  
Letters To The Editor ◽  
Fetal Circulation ◽  
Persistent Fetal Circulation ◽  
Gastric Hypersecretion

We thank Drs Goldenring and Franklin for their interest in our case report. Their theoretical concerns seem well founded and should be considered. The cases reported were infants without pulmonary hypertension or the need for tolazoline. It is of interest that a paper by Adams and colleagues in the very same issue of Pediatrics (62:298, 1980) reports on the use of cimetidine to treat gastric hypersecretion from chronic tolazoline administration in the syndrome of persistent fetal circulation.

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