Behavior of the13C lines in the ESR spectra of 3,6-di-tert-butyl-2-oxyphenoxyl with intramolecular hydrogen atom migration

1976 ◽  
Vol 25 (11) ◽  
pp. 2318-2322
Author(s):  
A. I. Prokof'ev ◽  
S. P. Solodovnikov ◽  
N. N. Bubnov ◽  
A. S. Masilimov
Keyword(s):  
Hydrogen Atom ◽  
Esr Spectra ◽  
Tert Butyl ◽  
Atom Migration ◽  
Intramolecular Hydrogen

Intramolecular hydrogen atom migration along the backbone of cationic and neutral radical tripeptides and subsequent radical-induced dissociations

2012 ◽  
Vol 14 (24) ◽  
pp. 8723 ◽  
Author(s):  
Junfang Zhao ◽  
Tao Song ◽  
Minjie Xu ◽  
Quan Quan ◽  
K. W. Michael Siu ◽  
...  
Keyword(s):  
Hydrogen Atom ◽  
Neutral Radical ◽  
Atom Migration ◽  
Intramolecular Hydrogen

Synthesis of Spongidine A, D and Petrosaspongiolide L Methyl Ester Using Pyridine C-H Functionalization

2019 ◽  
Author(s):  
Florian Bartels ◽  
Manuela Weber ◽  
Mathias Christmann
Keyword(s):  
Natural Products ◽  
Methyl Ester ◽  
Hydrogen Atom ◽  
Phospholipase A2 ◽  
Late Stage ◽  
Hydrogen Atom Transfer ◽  
Ring System ◽  
Tetracyclic Core ◽  
Intramolecular Hydrogen ◽  
Phospholipase A2 Inhibitors

<div>An efficient strategy for the synthesis of the potent phospholipase A2 inhibitors spongidine A and D is presented. The tetracyclic core of the natural products was assembled via an intramolecular hydrogen atom transfer‐initiated Minisci reaction. A divergent late‐stage functionalization of the tetracyclic ring system was also used to achieve a concise synthesis of petrosaspongiolide L methyl ester.</div>

2-Deoxyribose Radicals in the Gas Phase and Aqueous Solution. Transient Intermediates of Hydrogen Atom Abstraction from 2-Deoxyribofuranose

2005 ◽  
Vol 70 (11) ◽  
pp. 1769-1786 ◽  
Author(s):  
Luc A. Vannier ◽  
Chunxiang Yao ◽  
František Tureček
Keyword(s):  
Aqueous Solution ◽  
Hydrogen Atom ◽  
Gas Phase ◽  
Computational Study ◽  
Hydrogen Atom Abstraction ◽  
Oh Radical ◽  
Free Energies ◽  
Intramolecular Hydrogen ◽  
Solvation Free Energies ◽  
Transient Intermediates

A computational study at correlated levels of theory is reported to address the structures and energetics of transient radicals produced by hydrogen atom abstraction from C-1, C-2, C-3, C-4, C-5, O-1, O-3, and O-5 positions in 2-deoxyribofuranose in the gas phase and in aqueous solution. In general, the carbon-centered radicals are found to be thermodynamically and kinetically more stable than the oxygen-centered ones. The most stable gas-phase radical, 2-deoxyribofuranos-5-yl (5), is produced by H-atom abstraction from C-5 and stabilized by an intramolecular hydrogen bond between the O-5 hydroxy group and O-1. The order of radical stabilities is altered in aqueous solution due to different solvation free energies. These prefer conformers that lack intramolecular hydrogen bonds and expose O-H bonds to the solvent. Carbon-centered deoxyribose radicals can undergo competitive dissociations by loss of H atoms, OH radical, or by ring cleavages that all require threshold dissociation or transition state energies >100 kJ mol-1. This points to largely non-specific dissociations of 2-deoxyribose radicals when produced by exothermic hydrogen atom abstraction from the saccharide molecule. Oxygen-centered 2-deoxyribose radicals show only marginal thermodynamic and kinetic stability and are expected to readily fragment upon formation.

scholarly journals Infrared Photoactivation Reduces Peptide Folding and Hydrogen-Atom Migration following ETD Tandem Mass Spectrometry

2009 ◽  
Vol 48 (45) ◽  
pp. 8526-8528 ◽  
Author(s):  
Aaron R. Ledvina ◽  
Graeme C. McAlister ◽  
Myles W. Gardner ◽  
Suncerae I. Smith ◽  
James A. Madsen ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Hydrogen Atom ◽  
Tandem Mass Spectrometry ◽  
Peptide Folding ◽  
Tandem Mass ◽  
Atom Migration
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