Cholinergic hyperinnervation in the cerebral cortex of microencephalic rats does not result in muscarinic receptor down-regulation or in alteration of receptor-stimulated phosphoinositide metabolism

1992 ◽  
Vol 17 (8) ◽  
pp. 761-766 ◽  
Author(s):  
Walter Balduini ◽  
Gabriella Lombardelli ◽  
Guidubaldo Peruzzi ◽  
Flaminio Cattabeni
Keyword(s):  
Cerebral Cortex ◽  
Muscarinic Receptor ◽  
Phosphoinositide Metabolism ◽  
Down Regulation

scholarly journals Rapid accumulation and sustained turnover of inositol phosphates in cerebral-cortex slices after muscarinic-receptor stimulation

1989 ◽  
Vol 260 (1) ◽  
pp. 237-241 ◽  
Author(s):  
I H Batty ◽  
S R Nahorski
Keyword(s):  
Cerebral Cortex ◽  
Muscarinic Receptor ◽  
Metabolic Flux ◽  
Inositol Phosphates ◽  
Inositol Phosphate ◽  
Receptor Activation ◽  
Inositol Polyphosphate ◽  
Receptor Stimulation ◽  
Cortex Slices ◽  
Rapid Kinetics

The rapid kinetics of [3H]inositol phosphate accumulation and turnover were examined in rat cerebral-cortex slices after muscarinic-receptor stimulation. Markedly increased [3H]inositol polyphosphate concentrations were observed to precede significant stimulated accumulation of [3H]inositol monophosphate. New steady-state accumulations of several 3H-labelled products were achieved after 5-10 min of continued agonist stimulation, but were rapidly and effectively reversed by subsequent receptor blockade. The results show that muscarinic-receptor activation involves phosphoinositidase C-catalysed hydrolysis initially of polyphosphoinositides rather than of phosphatidylinositol. Furthermore, prolonged carbachol stimulation is shown not to cause receptor desensitization, but to allow persistent hydrolysis of [3H]phosphatidylinositol bisphosphate and permit sustained metabolic flux through the inositol tris-/tetrakis-phosphate pathway.

Down-regulation of phospholipase C-β1 following chronic muscarinic receptor activation

1998 ◽  
Vol 346 (1) ◽  
pp. R1-R2 ◽  
Author(s):  
Scott D Sorensen ◽  
Daniel A Linseman ◽  
Stephen K Fisher
Keyword(s):  
Phospholipase C ◽  
Muscarinic Receptor ◽  
Receptor Activation ◽  
Down Regulation
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