Disulfiram lowers Ca2+, Mg2+-ATPase activity of rat brain synaptosomes

1994 ◽  
Vol 19 (12) ◽  
pp. 1509-1513 ◽  
Author(s):  
S. N. Nagendra ◽  
K. Mamatha Rao ◽  
M. N. Subhash ◽  
K. Taranath Shetty
Keyword(s):  
Atpase Activity ◽  
Rat Brain ◽  
Rat Brain Synaptosomes ◽  
Brain Synaptosomes

Digitalis-like biological activity in rat cerebellum

1986 ◽  
Vol 64 (10) ◽  
pp. 1049-1053 ◽  
Author(s):  
Steven P. Lintlop ◽  
Bill Durante ◽  
Fred A. Sunahara ◽  
Amar K. Sen
Keyword(s):  
Biological Activity ◽  
Guinea Pig ◽  
Atpase Activity ◽  
Rat Brain ◽  
Inhibitory Activity ◽  
Regulatory Mechanism ◽  
Ouabain Binding ◽  
Rat Brain Synaptosomes ◽  
Rat Cerebellum ◽  
Brain Synaptosomes

The cytosolic fraction of rat cerebellum possesses a factor(s) which is capable of inhibiting synaptosomal Na,K-ATPase activity, competing with [3H]ouabain binding to rat brain synaptosomes, and inducing positive inotropy in guinea pig atrial strips. These results demonstrate the existence of a ouabain-like principle in rat cerebella. The inhibitory activity of the factor was found to be partially thermolabile and diminished by a proteolytic agent, and the activity could be augmented by increasing concentrations of Mg2+, suggesting a regulatory mechanism for the endogenous digitalis-like principle.

Toxaphene Inhibition of Calmodulin-Dependent Calcium ATPase Activity in Rat Brain Synaptosomes

1986 ◽  
Vol 6 (4) ◽  
pp. 648-653
Author(s):  
K. S. PRASADA RAO ◽  
C. H. TROTTMAN ◽  
W. MORROW ◽  
D. DESAIAH
Keyword(s):  
Atpase Activity ◽  
Rat Brain ◽  
Calcium Atpase ◽  
Rat Brain Synaptosomes ◽  
Brain Synaptosomes
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