Perinatal changes in amino acid metabolism of rat brain, especially alanine and glutamic acid

1980 ◽  
Vol 5 (10) ◽  
pp. 1117-1125 ◽  
Author(s):  
Tetsuya Noguchi ◽  
Masahiko Nomura ◽  
Yasuzo Tsukada
Keyword(s):  
Amino Acid ◽  
Glutamic Acid ◽  
Rat Brain ◽  
Amino Acid Metabolism ◽  
Acid Metabolism

Influence of Phenobarbital Anesthesia on Carbohydrate and Amino Acid Metabolism in Rat Brain

1978 ◽  
Vol 48 (3) ◽  
pp. 175-182 ◽  
Author(s):  
Astrid G. Chapman ◽  
Carl-Henrik Nordström ◽  
Bo K. Siesjo
Keyword(s):  
Amino Acid ◽  
Rat Brain ◽  
Amino Acid Metabolism ◽  
Acid Metabolism

Amino acid content of chronic undercut cortex of the cat in reletion to electrical afterdisctrarge: comparison with cobalt epileptogenic lesions

1977 ◽  
Vol 55 (3) ◽  
pp. 523-536 ◽  
Author(s):  
I. Koyama ◽  
H. Jasper
Keyword(s):  
Cerebral Cortex ◽  
Electrical Stimulation ◽  
Amino Acid ◽  
Glutamic Acid ◽  
Aspartic Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Amino Acid Content ◽  
Opposite Hemisphere ◽  
Afterdischarge Threshold

Chronic undercutting of cerebral cortex in the cat for survival periods of 9 to 308 days was found to cause an increase in duration of epileptiform electrical, afterdischarge and a significant decrease in content of glutamic acid, GABA, and aspartic acid as compared with homologous cortex of opposite hemisphere. These changes were comparable (though less marked) with changes previously found in cobalt-induced experimental epileptogenic lesions. Rate of release of GABA, glutamic acid, and aspartic acid into superfusates of undercut cortex at rest was higher in undercut cortex and was increased further by electrical stimulation. It was concluded that chronic partial denervation of cerebral cortex causes prolonged changes in metabolism or storage of glutamic acid, GABA, and aspartic acid probably related to increased tendency to prolonged epileptiform discharge similar in some respects (though not all) to changes observed in cobalt-induced cortical epileptogenic lesions. However, electrical afterdischarge threshold was not reduced in chronically undercut cortex and prolonged afterdischarge was not necessarily related to concentration of GABA in superfusate from undercut cortex, suggesting that factors other than amino acid metabolism may be also involved in mechanisms of epileptogenesis in undercut cortex.

scholarly journals Metabolic Activity Related to the Potassium Pump in the Midgut of Bombyx Mori Larvae

1985 ◽  
Vol 116 (1) ◽  
pp. 69-78
Author(s):  
P. PARENTI ◽  
B. GIORDANA ◽  
V. F. SACCHI ◽  
G. M. HANOZET ◽  
A. GUERRITORE
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Glutamic Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Tricarboxylic Acid Cycle ◽  
Electrical Potential ◽  
Tricarboxylic Acid ◽  
Electrical Potential Difference ◽  
Acid Cycle

The transepithelial electrical potential difference across the isolated midgut of Bombyx mori larvae is dependent on the presence of potassium and is unaffected by the addition of hexoses to perfusion media, whereas it is enhanced by alanine, aspartic acid, glutamic acid and the corresponding 2- oxoacids, glutamine and malate. The midgut enzyme profile indicates that the substrates for the tricarboxylic acid cycle are supplied mainly by amino acid metabolism via transaminases. Accordingly, aminoxyacetate drastically reduces the intestinal transepithelial electrical potential difference stimulated by amino acids. Measurement of the free amino acid concentration in the lumen content, intestinal cells and haemolymph shows that glutamic acid, asparagine and glutamine are accumulated in the cell, whilst the haemolymph is enriched with basic amino acids and with glycine, alanine, serine and tyrosine, the major components of the silk fibroin. Therefore, amino acid metabolism directly related to the tricarboxylic acid cycle seems to be the primary source of energy for the potassium pump activity in B. mori midgut.

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