Effects of acute hypoxia on incorporation of [1-14C]arachidonic acid into glycerolipids of rat brain

1981 ◽  
Vol 6 (7) ◽  
pp. 767-774 ◽  
Author(s):  
Joanna Strosznajder ◽  
Grace Y. Sun
2017 ◽  
Vol 55 (4) ◽  
pp. 3328-3343 ◽  
Author(s):  
Chih-Chung Lin ◽  
Chien-Chung Yang ◽  
Yu-Wen Chen ◽  
Li-Der Hsiao ◽  
Chuen-Mao Yang

1990 ◽  
Vol 10 (3) ◽  
pp. 358-364 ◽  
Author(s):  
F. Tegtmeier ◽  
C. Weber ◽  
U. Heister ◽  
I. Haker ◽  
D. Scheller ◽  
...  

The effects of complete ischemia on cerebral arachidonic acid (AA) metabolism were investigated in the isolated perfused rat brain. During 12.5 min of ischemia, AA, 5-hydroxy-6,8,11,14-eicosatetraenoic acid, and 15-hydroxy-5,8,11,13-eicosatetraenoic acid increased 129-, 4-, and 10-fold, respectively, while subsequent reperfusion for 30 min resulted in normalized levels independently of the duration of preceding ischemia. Prostaglandin (PG) F2α, PGE2, PGD2, 6-keto-PGF1α, and thromboxane (Tx) B2 remained at preischemic levels during 12.5 min of complete ischemia. However, at the end of subsequent reperfusion for 30 min, the levels of the prostanoids PGF2α, PGE2, PGD2, 6-keto-PGF1α, and TxB2 increased according to the preceding ischemic time. The levels reached a maximum after 7.5 min of ischemia and were elevated by 7-, 14-, 48-, 3-, and 30-fold, respectively. A prolongation of ischemia of up to 12.5 min was not associated with further increases of prostanoids at the end of reperfusion. The mechanisms underlying the metabolism of eicosanoids are discussed in relation to the changes of cortical direct current potential.


2021 ◽  
Vol 764 ◽  
pp. 136244
Author(s):  
Elie Farhat ◽  
Maiah E.M. Devereaux ◽  
Hang Cheng ◽  
Jean-Michel Weber ◽  
Matthew E. Pamenter

Stroke ◽  
1996 ◽  
Vol 27 (5) ◽  
pp. 971-979 ◽  
Author(s):  
Nabil J. Alkayed ◽  
Jayashree Narayanan ◽  
Debebe Gebremedhin ◽  
Meetha Medhora ◽  
Richard J. Roman ◽  
...  

2008 ◽  
Vol 33 (7) ◽  
pp. 1373-1383 ◽  
Author(s):  
Mireille Basselin ◽  
Lisa Chang ◽  
Mei Chen ◽  
Jane M. Bell ◽  
Stanley I. Rapoport

1983 ◽  
Vol 1 (3) ◽  
pp. 163-170 ◽  
Author(s):  
Laurie Foudin ◽  
Joanna Strosznajder ◽  
Grace Y. Sun

2000 ◽  
Vol 387 (2) ◽  
pp. 205-210 ◽  
Author(s):  
Zoltán Szupera ◽  
Zsófia Mezei ◽  
Béla Kis ◽  
Árpád Gecse ◽  
László Vécsei ◽  
...  

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