High-affinity uptake of ?-aminobutyric acid in cultured glial and neuronal cells

1979 ◽  
Vol 4 (3) ◽  
pp. 339-354 ◽  
Author(s):  
V. J. Balcar ◽  
J. Mark ◽  
J. Borg ◽  
P. Mandel
Keyword(s):  
Neuronal Cells ◽  
Aminobutyric Acid ◽  
High Affinity ◽  
High Affinity Uptake

High affinity uptake of L-glutamate and γ-aminobutyric acid inDrosophila melanogaster

1987 ◽  
Vol 11 (1-4) ◽  
pp. 119-135 ◽  
Author(s):  
C. S. Ramarao ◽  
S. R. Acharya ◽  
K. S. Krishnan ◽  
U. W. Kenkare
Keyword(s):  
Aminobutyric Acid ◽  
High Affinity ◽  
High Affinity Uptake

High-affinity uptake of ?-[3H]aminobutyric acid by isolated mouse oligodendrocytes in culture

1987 ◽  
Vol 12 (10) ◽  
pp. 885-890 ◽  
Author(s):  
Richard Reynolds ◽  
Christine Steffen ◽  
Norbert Herschkowitz
Keyword(s):  
Aminobutyric Acid ◽  
High Affinity ◽  
High Affinity Uptake

scholarly journals Exosome-Mediated Activation of Neuronal Cells Triggered by γ-Aminobutyric Acid (GABA)

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2544
Author(s):  
Ryo Inotsuka ◽  
Miyako Udono ◽  
Atsushi Yamatsu ◽  
Mujo Kim ◽  
Yoshinori Katakura
Keyword(s):  
Oral Administration ◽  
Memory Function ◽  
Neuronal Cells ◽  
Neuronal Cell ◽  
Enrichment Analysis ◽  
Gene Set Enrichment Analysis ◽  
Aminobutyric Acid ◽  
Intestinal Cells ◽  
Cell Functions ◽  
Expression Of Genes

γ-Aminobutyric acid (GABA) is a potent bioactive amino acid, and several studies have shown that oral administration of GABA induces relaxation, improves sleep, and reduces psychological stress and fatigue. In a recent study, we reported that exosomes derived from GABA-treated intestinal cells serve as signal transducers that mediate brain–gut interactions. Therefore, the purpose of this study was to verify the functionality of GABA-derived exosomes and to examine the possibility of improving memory function following GABA administration. The results showed that exosomes derived from GABA-treated intestinal cells (Caco-2) activated neuronal cells (SH-SY5Y) by regulating genes related to neuronal cell functions. Furthermore, we found that exosomes derived from the serum of GABA-treated mice also activated SH-SY5Y cells, indicating that exosomes, which are capable of activating neuronal cells, circulate in the blood of mice orally administered GABA. Finally, we performed a microarray analysis of mRNA isolated from the hippocampus of mice that were orally administered GABA. The results revealed changes in the expression of genes related to brain function. Gene Set Enrichment Analysis (GSEA) showed that oral administration of GABA affected the expression of genes related to memory function in the hippocampus.

scholarly journals The structural basis for high‐affinity uptake of lignin‐derived aromatic compounds by proteobacterial TRAP transporters

FEBS Journal ◽  
2021 ◽  
Author(s):  
Claudine Bisson ◽  
Robert C. Salmon ◽  
Laura West ◽  
John B. Rafferty ◽  
Andrew Hitchcock ◽  
...  
Keyword(s):  
Aromatic Compounds ◽  
Structural Basis ◽  
High Affinity ◽  
High Affinity Uptake
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