Synthesis of 2-alkylcyclododecanones by alkylation of cyclododecanone by n-alkyl halides under phase-transfer-catalysis conditions

1990 ◽  
Vol 39 (5) ◽  
pp. 976-977
Author(s):  
L. I. Zakharkin ◽  
I. M. Churilova ◽  
E. V. Anikina
Keyword(s):  
Phase Transfer Catalysis ◽  
Phase Transfer ◽  
Alkyl Halides

Pyrrole chemistry. XVII. Alkylation of the pyrrolyl ambident anion

1977 ◽  
Vol 55 (23) ◽  
pp. 4112-4116 ◽  
Author(s):  
Nam-Chiang Wang ◽  
Kang-Er Teo ◽  
Hugh J. Anderson
Keyword(s):  
Phase Transfer Catalysis ◽  
Phase Transfer ◽  
Alkyl Halides ◽  
Optimum Conditions ◽  
Alkylation Product ◽  
Ambident Anion ◽  
Series Of Experiments ◽  
C And N ◽  
Substituted Pyrroles

A series of experiments were carried out to find optimum conditions for C- and N-alkylation of the pyrrolyl ambident anion. While almost total C-alkylation could be obtained, isolation of a single alkylation product was not feasible. However, N-alkylation of pyrrole and several 2-substituted pyrroles was readily achieved by phase transfer catalysis with primary alkyl halides.

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