Reaction chromatography-mass spectrometry 1. Gas chromatograph -hydrogenation microreactor-mass spectrometer system for the study of olefins

1982 ◽  
Vol 31 (10) ◽  
pp. 1999-2005
Author(s):  
A. I. Mikaya ◽  
V. I. Smetanin ◽  
V. G. Zaikin
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometer ◽  
Gas Chromatograph ◽  
Chromatography Mass Spectrometry ◽  
Mass Spectrometer System ◽  
Spectrometer System ◽  
Reaction Chromatography

Routine Use of a Flexible Gas Chromatograph—Mass Spectrometer—Computer System to Identify Drugs and Their Metabolites in Body Fluids of Overdose Victims

1974 ◽  
Vol 20 (2) ◽  
pp. 255-265 ◽  
Author(s):  
C E Costello ◽  
H S Hertz ◽  
T Sakai ◽  
K Biemann
Keyword(s):  
Mass Spectrometer ◽  
Drug Overdose ◽  
Body Fluid ◽  
Mass Spectra ◽  
Body Fluids ◽  
Gas Chromatograph ◽  
Emergency Situations ◽  
Mass Spectrometer System ◽  
Spectrometer System ◽  
Resolution Mass

Abstract We have assembled a computer-searchable collection of 300 mass spectra of drugs, metabolites, normal body-fluid constituents, and common sample contaminants, for use in conjunction with a gas chromatograph—low resolution mass spectrometer system. The system is designed for analysis of drugs in body fluids of comatose victims of accidental or deliberate ingestion of a drug overdose. The speed and generality of the method make it particularly useful for such emergency situations. It has now been in routine use for longer than two years, and its usefulness is illustrated by results obtained for several actual samples.

Gas Chromatography Mass Spectrometry: A Report on the State of the Art

1974 ◽  
Vol 28 (4) ◽  
pp. 305-317 ◽  
Author(s):  
Catherine Fenselau
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Mass Spectrometer ◽  
Isotope Analysis ◽  
Gas Chromatography Mass Spectrometry ◽  
Gas Chromatograph ◽  
Chromatography Mass Spectrometry ◽  
Pharmacology And Toxicology ◽  
Computerized Data Processing

Instrumental and technical aspects of the combination gas chromatograph mass spectrometer are discussed, with emphasis on the various ways in which the mass spectrometer can serve as a detector for the gas chromatograph. A number of examples of applications are presented, in which the gas chromatograph mass spectrometer is used in its various instrumental modes. Computerized data processing is reviewed, and examples of applications are presented. Most of the examples of applications are taken from pharmacology and toxicology. Special attention is given to stable isotope analysis and to the role of stable isotopes in quantitation by gas chromatography mass spectrometry of samples in the subnanogram range.

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