19F-NMR investigation of the comparative transmission capability of Hg-N bonds and the influence of the nature of the solvent on it

1981 ◽  
Vol 30 (4) ◽  
pp. 548-553 ◽  
Author(s):  
A. N. Nesmeyanov ◽  
S. I. Pombrik ◽  
E. V. Polunkin ◽  
L. S. Golovchenko ◽  
A. S. Peregudov ◽  
...  
Keyword(s):  
19F Nmr ◽  
Transmission Capability

19F NMR study of transmission capability of Hg-S and Sn-S binuclear bridge groupings

1983 ◽  
Vol 32 (4) ◽  
pp. 732-737
Author(s):  
S. I. Pombrik ◽  
L. S. Golovchenko ◽  
A. S. Peregudov ◽  
�. I. Fedin ◽  
D. N. Kravtsov
Keyword(s):  
19F Nmr ◽  
Nmr Study ◽  
Transmission Capability

Use of 19F NMR for studies of the complexation of gallium (III) by 5-fluoro-8-hydroxyquinoline

1998 ◽  
Vol 95 (2) ◽  
pp. 395-400
Author(s):  
O. Jarjayes ◽  
S. Hamman ◽  
C. G. Beguin
Keyword(s):  
19F Nmr

19F-NMR in Target-based Drug Discovery

2019 ◽  
Vol 26 (26) ◽  
pp. 4964-4983 ◽  
Author(s):  
CongBao Kang
Keyword(s):  
Drug Discovery ◽  
Conformational Changes ◽  
Protein Structures ◽  
19F Nmr ◽  
Binding Affinities ◽  
Protein Ligand Interactions ◽  
Compound Libraries ◽  
Ligand Interactions ◽  
Reference Ligand ◽  
Hit Identification

Solution NMR spectroscopy plays important roles in understanding protein structures, dynamics and protein-protein/ligand interactions. In a target-based drug discovery project, NMR can serve an important function in hit identification and lead optimization. Fluorine is a valuable probe for evaluating protein conformational changes and protein-ligand interactions. Accumulated studies demonstrate that 19F-NMR can play important roles in fragment- based drug discovery (FBDD) and probing protein-ligand interactions. This review summarizes the application of 19F-NMR in understanding protein-ligand interactions and drug discovery. Several examples are included to show the roles of 19F-NMR in confirming identified hits/leads in the drug discovery process. In addition to identifying hits from fluorinecontaining compound libraries, 19F-NMR will play an important role in drug discovery by providing a fast and robust way in novel hit identification. This technique can be used for ranking compounds with different binding affinities and is particularly useful for screening competitive compounds when a reference ligand is available.

Synthesis, Characterization, and Dynamic Behavior of Well-defined Dithiomaleimide-functionalized Maltodextrins

2020 ◽  
Vol 17 (2) ◽  
pp. 85-89
Author(s):  
Francisco J. Hidalgo ◽  
Nathan A.P. Lorentz ◽  
TinTin B. Luu ◽  
Jonathan D. Tran ◽  
Praveen D. Wickremasinghe ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Dynamic Behavior ◽  
Industrial Applications ◽  
19F Nmr ◽  
Nmr Studies ◽  
Synthetic Pathway ◽  
End Groups ◽  
Sugar End

: Maltodextrins have an increasing number of biomedical and industrial applications due to their attractive physicochemical properties such as biodegradability and biocompatibility. Herein, we describe the development of a synthetic pathway and characterization of thiol-responsive maltodextrin conjugates with dithiomaleimide linkages. 19F NMR studies were also conducted to demonstrate the exchange dynamics of the dithiomaleimide-functionalized sugar end groups.

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