Autoregulation of human optic nerve head blood flow in response to acute changes in ocular perfusion pressure

1997 ◽  
Vol 235 (10) ◽  
pp. 618-626 ◽  
Author(s):  
Charles E. Riva ◽  
Mark Hero ◽  
Patrick Titze ◽  
Beno Petrig
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Perfusion Pressure ◽  
Ocular Perfusion Pressure ◽  
Ocular Perfusion ◽  
Acute Changes ◽  
Human Optic Nerve

scholarly journals Role of nitric oxide in optic nerve head blood flow regulation while experimental increase of ocular perfusion pressure

2011 ◽  
Vol 11 (Suppl 2) ◽  
pp. A47
Author(s):  
Reinhard Told ◽  
Doreen Schmidl ◽  
Michael Lasta ◽  
Agnes Boltz ◽  
Berthold Pemp ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Perfusion Pressure ◽  
Flow Regulation ◽  
Ocular Perfusion Pressure ◽  
Ocular Perfusion ◽  
Blood Flow Regulation

Comparison of Choroidal and Optic Nerve Head Blood Flow Regulation during Changes in Ocular Perfusion Pressure

2012 ◽  
Vol 53 (8) ◽  
pp. 4337 ◽  
Author(s):  
Doreen Schmidl ◽  
Agnes Boltz ◽  
Semira Kaya ◽  
Rene Werkmeister ◽  
Nikolaus Dragostinoff ◽  
...  
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Perfusion Pressure ◽  
Flow Regulation ◽  
Ocular Perfusion Pressure ◽  
Ocular Perfusion ◽  
Blood Flow Regulation

scholarly journals Comparison of Optic Nerve Head Blood Flow Autoregulation among Quadrants Induced by Decreased Ocular Perfusion Pressure during Vitrectomy

2017 ◽  
Vol 2017 ◽  
pp. 1-6
Author(s):  
Ryuya Hashimoto ◽  
Tetsuya Sugiyama ◽  
Takatoshi Maeno
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Perfusion Pressure ◽  
Medical Center ◽  
Ocular Perfusion Pressure ◽  
Software Analysis ◽  
Ocular Perfusion ◽  
Significant Difference ◽  
Time Courses

Purpose. The present study aimed to examine changes in optic nerve head (ONH) blood flow autoregulation in 4 quadrants (superior, nasal, inferior, and temporal) with decreased ocular perfusion pressure (OPP) during vitrectomy in order to determine whether there is a significant difference of autoregulatory capacity in response to OPP decrease at each ONH quadrant. Methods. This study included 24 eyes with an epiretinal membrane or macular hole that underwent vitrectomy at Toho University Sakura Medical Center. Following vitrectomy, the tissue mean blur rate (MBR), which reflects ONH blood flow, was measured. Mean tissue MBRs in the four quadrants were generated automatically in the software analysis report. Measurements were conducted before and 5 and 10 min after intraocular pressure (IOP) elevation of approximately 15 mmHg in the subjects without systemic disorders. Results. The baseline tissue MBR of the temporal quadrant was significantly lower than that of the other 3 quadrants (all P<0.05). However, the time courses of tissue MBR in response to OPP decrease were not significantly different among the four quadrants during vitrectomy (P=0.23). Conclusions. There is no significant difference in the autoregulatory capacity of the four ONH quadrants in patients without systemic disorders during vitrectomy.

Variations in the Blood Flow of the Human Optic Nerve Head

1997 ◽  
Vol 7 (4) ◽  
pp. 364-369 ◽  
Author(s):  
R. Osuský ◽  
A. Schoetzau ◽  
J. Flammer
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Continuous Measurement ◽  
The Body ◽  
Flow Volume ◽  
Frequency Range ◽  
Flow Fluctuations ◽  
Human Optic Nerve ◽  
Doppler Flowmeter

Blood flow in various tissues of the body shows spontaneous variations. The purpose of this study was to analyze variations over time in the blood flow of the optic nerve head. Blood flow was measured by the laser Doppler flowmeter (LDF) in 12 healthy volunteers, and analyzed by spectral Fourier analysis. The LDF technique allows continuous measurement of flow, volume, and velocity in the microcirculation of the optic nerve head. We found variations expressed in cycles per minute (c/min) at frequencies characteristic of vasomotion (<10 c/min) of breathing, and of cardiac pulsation. Oscillations at frequency <10 c/min predominated in volume in all subjects and in flow in all but one. Variations in velocity of 60-90 c/min were identified in 10 of the 12 volunters. Oscillations in the range of breathing frequency made the smallest contribution to changes in blood flow. Fluctuations in the frequency range of 5 c/min and lower were observed most frequently, and the majority of subjects showed fluctuations of several frequencies. Our results provide evidence that blood flow in the human optic nerve head presents some characteristics already known from the general physiology of the microcirculation.

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