Sufficiency theorems for target capture

1975 ◽  
Vol 17 (5-6) ◽  
pp. 523-543 ◽  
Author(s):  
D. J. Sticht ◽  
T. L. Vincent ◽  
D. G. Schultz
Keyword(s):  
Sufficiency Theorems ◽  
Target Capture

scholarly journals HybPhaser: A workflow for the detection and phasing of hybrids in target capture data sets

2021 ◽  
Author(s):  
Lars Nauheimer ◽  
Nicholas Weigner ◽  
Elizabeth Joyce ◽  
Darren Crayn ◽  
Charles Clarke ◽  
...  
Keyword(s):  
Data Sets ◽  
Target Capture

scholarly journals Striatal and Pallidal Activation during Reward Modulated Movement Using a Translational Paradigm

2015 ◽  
Vol 21 (6) ◽  
pp. 399-411 ◽  
Author(s):  
Amanda Bischoff-Grethe ◽  
Richard B. Buxton ◽  
Martin P. Paulus ◽  
Adam S. Fleisher ◽  
Tony T. Yang ◽  
...  
Keyword(s):  
Visual Cues ◽  
Animal Studies ◽  
Target Location ◽  
Functional Neuroimaging ◽  
Dorsal Striatum ◽  
Imaging Study ◽  
Reward Processing ◽  
Neural Activation ◽  
Internal Globus Pallidus ◽  
Target Capture

AbstractHuman neuroimaging studies of reward processing typically involve tasks that engage decision-making processes in the dorsal striatum or focus upon the ventral striatum’s response to feedback expectancy. These studies are often compared to the animal literature; however, some animal studies include both feedback and nonfeedback events that activate the dorsal striatum during feedback expectancy. Differences in task parameters, movement complexity, and motoric effort to attain rewards may partly explain ventral and dorsal striatal response differences across species. We, therefore, used a target capture task during functional neuroimaging that was inspired by a study of single cell modulation in the internal globus pallidus during reward-cued, rotational arm movements in nonhuman primates. In this functional magnetic resonance imaging study, participants used a fiberoptic joystick to make a rotational response to an instruction stimulus that indicated both a target location for a capture movement and whether or not the trial would end with feedback indicating either a small financial gain or a neutral outcome. Portions of the dorsal striatum and pallidum demonstrated greater neural activation to visual cues predicting potential gains relative to cues with no associated outcome. Furthermore, both striatal and pallidal regions displayed a greater response to financial gains relative to neutral outcomes. This reward-dependent modulation of dorsal striatal and pallidal activation in a target-capture task is consistent with findings from reward studies in animals, supporting the use of motorically complex tasks as translational paradigms to investigate the neural substrates of reward expectancy and outcome in humans. (JINS, 2015, 21, 399–411)

scholarly journals BOLD Coherence Reveals Segregated Functional Neural Interactions When Adapting to Distinct Torque Perturbations

2007 ◽  
Vol 97 (3) ◽  
pp. 2107-2120 ◽  
Author(s):  
Eugene Tunik ◽  
Paul J. Schmitt ◽  
Scott T. Grafton
Keyword(s):  
Basal Ganglia ◽  
Contextual Information ◽  
Natural World ◽  
Adaptive Responses ◽  
Response Preparation ◽  
Target Capture ◽  
Neural Processes ◽  
Neural Interactions ◽  
The Right ◽  
Level Analysis

In the natural world, we experience and adapt to multiple extrinsic perturbations. This poses a challenge to neural circuits in discriminating between different context-appropriate responses. Using event-related fMRI, we characterized the neural dynamics involved in this process by randomly delivering a position- or velocity-dependent torque perturbation to subjects’ arms during a target-capture task. Each perturbation was color-cued during movement preparation to provide contextual information. Although trajectories differed between perturbations, subjects significantly reduced error under both conditions. This was paralleled by reduced BOLD signal in the right dentate nucleus, the left sensorimotor cortex, and the left intraparietal sulcus. Trials included “NoGo” conditions to dissociate activity related to preparation from execution and adaptation. Subsequent analysis identified perturbation-specific neural processes underlying preparation (“NoGo”) and adaptation (“Go”) early and late into learning. Between-perturbation comparisons of BOLD magnitude revealed negligible differences for both preparation and adaptation trials. However, a network-level analysis of BOLD coherence revealed that by late learning, response preparation (“NoGo”) was attributed to a relative focusing of coherence within cortical and basal ganglia networks in both perturbation conditions, demonstrating a common network interaction for establishing arbitrary visuomotor associations. Conversely, late-learning adaptation (“Go”) was attributed to a focusing of BOLD coherence between a cortical–basal ganglia network in the viscous condition and between a cortical–cerebellar network in the positional condition. Our findings demonstrate that trial-to-trial acquisition of two distinct adaptive responses is attributed not to anatomically segregated regions, but to differential functional interactions within common sensorimotor circuits.

scholarly journals Genome Sequences of Three Novel Isolates of Human Parainfluenza Virus 2 Associated with Acute Respiratory Infection

2017 ◽  
Vol 5 (33) ◽  
Author(s):  
J. L. Kennedy ◽  
J. C. Kincaid ◽  
K. C. Schwalm ◽  
A. N. Stoner ◽  
T. J. Abramo ◽  
...  
Keyword(s):  
Respiratory Infection ◽  
Acute Respiratory Infection ◽  
Pediatric Patients ◽  
Parainfluenza Virus ◽  
Accession Number ◽  
Genome Sequences ◽  
Viral Nucleic Acid ◽  
Target Capture ◽  
Human Parainfluenza Virus ◽  
Generation Sequencing

ABSTRACT Using target capture of viral nucleic acid and next-generation sequencing, we generated the genome sequences of three novel human parainfluenza virus 2 isolates. Isolates ACRI_0185 (GenBank accession number MF077311), ACRI_0230 (MF077312), and ACRI_0248 (MF077313) were collected in October 2016, February 2017, and March 2017, respectively, from pediatric patients with acute respiratory infection in Arkansas.

scholarly journals Mechanical design and analysis of a gripper for non-cooperative target capture in space

2018 ◽  
Vol 10 (11) ◽  
pp. 168781401881064 ◽  
Author(s):  
Yili Zheng ◽  
Guannan Lei ◽  
Mingwei Zhang ◽  
Qianbo Che
Keyword(s):  
Mechanical Design ◽  
Three Dimensional ◽  
Simulation Software ◽  
Microgravity Environment ◽  
Three Dimensional Modeling ◽  
Target Capture ◽  
Model Collision ◽  
Rigid Connection ◽  
Aluminum Honeycomb ◽  
Ground Test

Space grippers are the key devices for accomplishing space non-cooperative target capture, which has a great significance for satellite services and space debris removal. This article proposes a novel mechanical gripper device for the capture of aluminum honeycomb panels of non-cooperative satellites. The gripper was modeled and assembled in the three-dimensional modeling platform UGNX. The model was imported into the simulation software ADAMS. ADAMS is capable of analyzing the kinematic feasibility of the gripper model. Collision and penetrating power analysis of the mechanical claws into an aluminum honeycomb plate were carried out in LS-DYNA. Through non-vertical piercing experiment, the maximum approaching angle tolerance is 10°. The established rigid connection can withstand a destructive force greater than 1000 N. A prototype of the mechanical gripper is built. A ground test was carried out with this prototype, in which a test-platform simulated the space microgravity environment. The results certified that the prototype could reach the target at a relative speed of 0.5 m/s and then quickly complete the grabbing motion and establish a rigid connection. The experiment shows that this mechanical gripper can accomplish the task of repeatedly capturing the surface of non-cooperative space satellites.

scholarly journals Clinical and genetic diagnosis of thirteen Japanese patients with hereditary spherocytosis

2022 ◽  
Vol 9 (1) ◽  
Author(s):  
Keiko Shimojima Yamamoto ◽  
Taiju Utshigisawa ◽  
Hiromi Ogura ◽  
Takako Aoki ◽  
Takahiro Kawakami ◽  
...  
Keyword(s):  
Hemolytic Anemia ◽  
Hereditary Spherocytosis ◽  
Genetic Diagnosis ◽  
Genomic Analysis ◽  
Japanese Patients ◽  
Asian Countries ◽  
Target Capture ◽  
Detailed Family History ◽  
Target Capture Sequencing ◽  
Chronic Hemolytic Anemia

AbstractHereditary spherocytosis is the most frequent cause of hereditary hemolytic anemia and is classified into five subtypes (SPH1-5) according to OMIM. Because the clinical and laboratory features of patients with SPH1-5 are variable, it is difficult to classify these patients into the five subtypes based only on these features. We performed target capture sequencing in 51 patients with hemolytic anemia associated with/without morphological abnormalities in red blood cells. Thirteen variants were identified in five hereditary spherocytosis-related genes (six in ANK1 [SPH1]; four in SPTB [SPH2]; and one in each of SPTA1 [SPH3], SLC4A1 [SPH4], and EPB42 [SPH5]). Among these variants, seven were novel. The distribution pattern of the variants was different from that reported previously in Japan but similar to those reported in other Asian countries. Comprehensive genomic analysis would be useful and recommended, especially for patients without a detailed family history and those receiving frequent blood transfusions due to chronic hemolytic anemia.

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