New and recurrent tumor foci following local treatment as well as external beam radiation in eyes of patients with hereditary retinoblastoma

1990 ◽  
Vol 228 (5) ◽  
pp. 426-431 ◽  
Author(s):  
Elmar P. Messmer ◽  
Wolfgang Sauerwein ◽  
Thomas Heinrich ◽  
Wolfgang H�pping ◽  
Doris Klueter-Reckmann ◽  
...  
The Prostate ◽  
2017 ◽  
Vol 77 (6) ◽  
pp. 686-693 ◽  
Author(s):  
Raisa S. Pompe ◽  
Helen Davis-Bondarenko ◽  
Emanuele Zaffuto ◽  
Zhe Tian ◽  
Shahrokh F. Shariat ◽  
...  

2015 ◽  
Vol 94 (4) ◽  
pp. 373-382 ◽  
Author(s):  
Deliu Victor Matei ◽  
Matteo Ferro ◽  
Barbara Alicja Jereczek-Fossa ◽  
Giuseppe Renne ◽  
Nicolae Crisan ◽  
...  

Background: Radical external beam radiotherapy (EBRT) is a standard treatment for prostate cancer patients. Despite this, the rate of intraprostatic relapses after primary EBRT is still not negligible. There is no consensus on the most appropriate management of these patients after EBRT failure. For these patients, local salvage therapy such as radical prostatectomy, cryotherapy, and brachytherapy may be indicated. Objective: The objectives of this review were to analyze the eligibility criteria for careful selection of appropriate patients and to evaluate the oncological results and complications for each method. Methods: A review of the literature was performed to identify studies of local salvage therapy for patients who had failed primary EBRT for localized prostate cancer. Results: Most studies demonstrated that local salvage therapy after EBRT may provide long-term local control in appropriately selected patients, although toxicity is often significant. Conclusions: Our results suggest that for localized prostate cancer recurrence after EBRT, the selection of a local treatment modality should be made on a patient-by-patient basis. An improvement in selection criteria and an integrated definition of biochemical failure for all salvage methods are required to determine which provides the best oncological outcome and least comorbidity.


2018 ◽  
Vol 28 (1) ◽  
pp. 188-193 ◽  
Author(s):  
Wei-Hsien Hou ◽  
Tim E. Schultheiss ◽  
Jeffrey Y. Wong ◽  
Mark T. Wakabayashi ◽  
Yi-Jen Chen

ObjectivesThe objective of this study was to assess treatment and other factors impacting survival in cervical high-grade neuroendocrine carcinoma (HGNEC).Methods/MaterialsWe identified patients with cervical HGNECs diagnosed during 1988 to 2012 in the Surveillance Epidemiology and End Results database. We determined overall survival by International Federation of Gynecology and Obstetrics stages and by local treatment modalities, that is, radical surgery versus external beam radiation treatment (EBRT) plus brachytherapy using Kaplan-Meier analysis with log-rank test. We also determined factors of age, stage, and treatment modality impacting survival using proportional hazard analysis.ResultsWe identified 832 cases of cervical HGNECs in the database. After excluding cases with incomplete stage data, the International Federation of Gynecology and Obstetrics stages I to IV distributions were 196 (28.0%), 69 (9.9%), 175 (25.0%), and 260 patients (37.1%), respectively. Radical surgery and primary radiotherapy yielded similar 5-year overall survival for stages I (61% vs 53%,P= 0.27), II (48% vs 28%,P= 0.308), and III (33% vs 28%,P= 0.408) patients. External beam radiation treatment plus brachytherapy did not yield superior survival than EBRT alone in stage I (48% vs 49%,P= 0.799), II (37% vs 20%,P= 0.112), or III (25% vs 32%,P= 0.636) patients. Age (P= 0.004) and stage (stage II: hazard ratio [HR], 1.78,P= 0.013; stage III: HR, 2.42;P< 0.001) were independent factors impacting survival but not local treatment modality (EBRT: HR, 1.30,P= 0.17; EBRT plus brachytherapy: HR, 1.16;P= 0.417).ConclusionsPatients with cervical HGNECs had poor prognosis. Primary treatment by radical surgery or external beam radiotherapy with or without brachytherapy yielded equally poor survival.


2007 ◽  
Vol 177 (4S) ◽  
pp. 376-377 ◽  
Author(s):  
Bryan J. Donnelly ◽  
John C. Saliken ◽  
Penny Brasher ◽  
Scott Ernst ◽  
Harold Lau ◽  
...  

10.37206/88 ◽  
2005 ◽  
Author(s):  
Ellen Yorke ◽  
Rodica Alecu ◽  
Li Ding ◽  
Doracy Fontenla ◽  
Andre Kalend ◽  
...  

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