Domoic acid inhibits adenylate cyclase activity in rat brain membranes

1994 ◽  
Vol 136 (2) ◽  
pp. 105-111 ◽  
Author(s):  
M. S. Nijjar ◽  
B. Grimmelt
Keyword(s):  
Adenylate Cyclase ◽  
Rat Brain ◽  
Domoic Acid ◽  
Cyclase Activity ◽  
Adenylate Cyclase Activity ◽  
Brain Membranes ◽  
Rat Brain Membranes

Galanin inhibits adenylate cyclase of rat brain membranes

Peptides ◽  
1992 ◽  
Vol 13 (2) ◽  
pp. 339-341 ◽  
Author(s):  
Yaohui Chen ◽  
Marc Laburthe ◽  
Brigitte Amiranoff
Keyword(s):  
Adenylate Cyclase ◽  
Rat Brain ◽  
Brain Membranes ◽  
Rat Brain Membranes

scholarly journals Effects of noradrenaline on the activation and the stability of brain adenylate cyclase

1977 ◽  
Vol 166 (3) ◽  
pp. 473-483 ◽  
Author(s):  
S Brydon-Golz ◽  
H Ohanian ◽  
A Bennun
Keyword(s):  
Adenylate Cyclase ◽  
Rat Brain ◽  
Half Life ◽  
Brain Cortex ◽  
Corpus Striatum ◽  
Cyclase Activity ◽  
Adenylate Cyclase Activity ◽  
Strong Inhibition ◽  
The Stability ◽  
Stimulation Of

At constant 1 mM-ATP, the Mg2+-saturation curves for adenylate cyclase (EC 4.6.1.1) particulate preparations obtained from corpus striatum and cortex tissues of rat brain show that addition of 0.1 mM-noradrenaline increases the apparent Vmax. for Mg2+ by 300% in corpus striatum particles, and by 280% in cortex particles. At 10 mM-MgCl2, the addition of 0.1 mM-noradrenaline increased by 800% the adenylate cyclase activity of corpus striatum particles. At all Mg2+ concentrations, the addition of 0.3 mM-CaCl2 suppressed the noradrenaline-induced stimulation of adenylate cyclase of corpus striatum particles, and even resulted in a strong inhibition of the activating effect of Mg2+ itself on adenylate cyclase of corpus striatum particles, and even resulted in a strong inhibition of the activating effect of Mg2+ itself on adenylate cyclase activity of cortex particles. The addition of noradrenaline during a 3 h preincubation of particle preparations of brain cortex at 38 degrees C decreased by more than 4-fold the half-life of the decay of adenylate cyclase activity. The addition of MgATP protected against noradrenaline-induced inactivation.

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