Preparation of trimethylsilyl derivatives of amino acids and peptides for peptide synthesis

1974 ◽  
Vol 23 (8) ◽  
pp. 1789-1792 ◽  
Author(s):  
S. V. Rogozhin ◽  
Yu. A. Davidovich ◽  
S. M. Andreev ◽  
N. V. Mironova ◽  
A. I. Yurtanov
Keyword(s):  
Amino Acids ◽  
Peptide Synthesis ◽  
Trimethylsilyl Derivatives ◽  
Derivatives Of

N-Methylamino Acids in Peptide Synthesis. II. A New Synthesis of N-Benzyloxycarbonyl, N-Methylamino Acids

1973 ◽  
Vol 51 (12) ◽  
pp. 1915-1919 ◽  
Author(s):  
John R. McDermott ◽  
N. Leo Benoiton
Keyword(s):  
Amino Acids ◽  
Methyl Iodide ◽  
Peptide Synthesis ◽  
Side Chains ◽  
Butyl Group ◽  
New Synthesis ◽  
Derivatives Of

Reaction of N-benzyloxycarbonyl derivatives of aliphatic amino acids, and threonine, aspartic, and glutamic acids whose side-chains were protected with the t-butyl group, gave the corresponding N-methylamino acid derivatives in good yields. The methionine derivative could be obtained by using only one mol of methyl iodide. Derivatives of threonine, and aspartic and glutamic acids whose side-chains were not protected could not be methylated. Analysis of the crude products of methylation in three cases showed that they contained 0–1% of racemized material.

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