Hydrogen peroxide induces DNA single strand breaks in respiratory epithelial cells

Inflammation ◽  
1993 ◽  
Vol 17 (6) ◽  
pp. 715-722 ◽  
Author(s):  
Ruth J. McDonald ◽  
Lester C. Pan ◽  
Judith A. St. George ◽  
Dallas M. Hyde ◽  
Jonathan M. Ducore
Keyword(s):  
Hydrogen Peroxide ◽  
Epithelial Cells ◽  
Single Strand ◽  
Respiratory Epithelial Cells ◽  
Strand Breaks ◽  
Single Strand Breaks ◽  
Respiratory Epithelial

scholarly journals Cell killing and DNA damage by hydrogen peroxide are mediated by intracellular iron

1984 ◽  
Vol 218 (1) ◽  
pp. 273-275 ◽  
Author(s):  
A C Mello Filho ◽  
M E Hoffmann ◽  
R Meneghini
Keyword(s):  
Hydrogen Peroxide ◽  
Dna Damage ◽  
Hydroxyl Radicals ◽  
Iron Chelator ◽  
Single Strand ◽  
Intracellular Iron ◽  
Killing Effect ◽  
Strand Breaks ◽  
Single Strand Breaks ◽  
Mouse Cells

Phenanthroline, a strong iron chelator, prevents both the formation of DNA single-strand breaks and the killing of mouse cells produced by H2O2. These results, taken together with our previous findings, indicate that the DNA damage is produced by hydroxyl radicals formed when H2O2 reacts with chromatin-bound Fe2+ and that this damage is responsible for the killing effect.

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