Regulation of human natural killer (NK) cell function: Induction of killing of an NK-resistant renal carcinoma cell line

1988 ◽  
Vol 8 (1) ◽  
pp. 69-79 ◽  
Author(s):  
Melissa C. Kanar ◽  
Dwain L. Thiele ◽  
Monika �stensen ◽  
Peter E. Lipsky
Keyword(s):  
Natural Killer ◽  
Cell Line ◽  
Renal Carcinoma ◽  
Cell Function ◽  
Nk Cell ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Renal Carcinoma Cell Line

scholarly journals Stimulation by cAMP of erythropoietin secretion by an established human renal carcinoma cell line

Blood ◽  
1987 ◽  
Vol 69 (4) ◽  
pp. 1053-1057 ◽  
Author(s):  
JB Sherwood ◽  
ER Burns ◽  
D Shouval
Keyword(s):  
Cell Line ◽  
Renal Carcinoma ◽  
Carcinoma Cell ◽  
Phosphodiesterase Inhibitor ◽  
Adenosine Monophosphate ◽  
Carcinoma Cell Line ◽  
Biologically Active ◽  
Human Renal Carcinoma ◽  
Renal Carcinoma Cell Line

Abstract We used our recently reported stable, transformed human renal carcinoma cell line as a model system to study the role of 3′,5′-adenosine monophosphate (cAMP) in erythropoietin secretion. The erythropoietin produced by these cells is both biologically active and immunologically cross-reactive with purified native human hormone in our radioimmunoassay. Erythropoietin release by these renal carcinoma cells appears to be stimulated by cAMP as well as by the phosphodiesterase inhibitor 3-isobutyl-1-methyl-xanthine (MIX). The response to cAMP involves a rapid and enhanced release of hormone, which occurred within 30 minutes of exposure of the cells to the effector and continued for at least 4 hours. Intracellular erythropoietin was higher in the control cultures than in the cells treated with cAMP, suggesting that cAMP stimulates the release of a storage pool of hormone. The ability of cAMP and MIX to elicit the release of erythropoietin suggests that a cAMP-mediated mechanism is involved in the release of this hormone.

scholarly journals Establishment and characterization of a highly immunogenic human renal carcinoma cell line

2016 ◽  
Vol 49 (2) ◽  
pp. 457-470 ◽  
Author(s):  
Clelia Prattichizzo ◽  
Margherita Gigante ◽  
Paola Pontrelli ◽  
Alessandro Stella ◽  
Maria Teresa Rocchetti ◽  
...  
Keyword(s):  
Cell Line ◽  
Renal Carcinoma ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Human Renal Carcinoma ◽  
Renal Carcinoma Cell Line
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