Interaction of Mannich bases with triethyl phosphite

1969 ◽  
Vol 18 (4) ◽  
pp. 753-756
Author(s):  
B. E. Ivanov ◽  
V. F. Zheltukhin
Keyword(s):  
Triethyl Phosphite ◽  
Mannich Bases

Reactions of Mannich bases with triethyl phosphite

1967 ◽  
Vol 16 (6) ◽  
pp. 1239-1242 ◽  
Author(s):  
B. E. Ivanov ◽  
V. F. Zheltukhin ◽  
T. G. Vavilova
Keyword(s):  
Triethyl Phosphite ◽  
Mannich Bases

Kinetics of the interaction of phenolic Mannich bases with triethyl phosphite

1971 ◽  
Vol 20 (10) ◽  
pp. 2068-2070
Author(s):  
B. E. Ivanov ◽  
L. A. Valitova ◽  
L. A. Khismatullina ◽  
M. Sh. Yagfarov
Keyword(s):  
Triethyl Phosphite ◽  
Mannich Bases ◽  
Kinetics Of

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME O-CRESOL MANNICH BASES

2016 ◽  
Vol 4 (11) ◽  
pp. 892-899
Author(s):  
AbdelKarim M. ◽  
◽  
Wafa O. ◽  
Nafesa A.G. ◽  
Inas O. ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Mannich Bases

Cytotoxicity of Hydrazones of Morpholine Bearing Mannich Bases Towards Huh7 and T47D Cell Lines and Their Effects on Mitochondrial Respiration

2016 ◽  
Vol 13 (8) ◽  
pp. 734-741 ◽  
Author(s):  
Kaan Kucukoglu ◽  
Halise Inci Gul ◽  
Mustafa Gul ◽  
Rengul Cetin-Atalay ◽  
Yosra Baratli ◽  
...  
Keyword(s):  
Cell Lines ◽  
Mitochondrial Respiration ◽  
T47d Cell ◽  
Mannich Bases

Synthesis and Cytotoxicity of New Mannich Bases of 6-[3-(3,4,5-Trimetoxyphenyl)-2- propenoyl]-2(3H)-Benzoxazolone

2020 ◽  
Vol 17 (4) ◽  
pp. 512-517
Author(s):  
Ognyan Ivanov Petrov ◽  
Yordanka Borisova Ivanova ◽  
Mariana Stefanova Gerova ◽  
Georgi Tsvetanov Momekov
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Biological Activities ◽  
Human Tumor ◽  
Mannich Bases ◽  
In Vitro Cytotoxicity ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines

Background: Chemotherapy is one of the mainstays of cancer treatment, despite the serious side effects of the clinically available anticancer drugs. In recent years increasing attention has been directed towards novel agents with improved efficacy and selectivity. Compounds with chalcone backbone have been reported to possess various biological activities such as anticancer, antimicrobial, anti-inflammatory, analgesic, antioxidant, etc. It was reported that aminomethylation of hydroxy chalcones to the corresponding Mannich bases increased their cytotoxicity. In this context, our interest has been focused on the design and synthesis of the so-called multi-target molecules, containing two or more pharmacophore fragments. Methods: A series of Mannich bases were synthesized by the reaction between 6-[3-(3,4,5- trimethoxyphenyl)-2-propenoyl]-2(3Н)-benzoxazolone, formaldehyde, and a secondary amine. The structures of the compounds were confirmed by elemental analysis, IR and NMR spectra. The new Mannich bases were evaluated for their in vitro cytotoxicity against a panel of human tumor cell lines, including BV-173, SKW-3, K-562, HL-60, HD-MY-Z and MDA-MB-231. The effects of selected compounds on the cellular levels of glutathione (GSH) were determined. Results: The new compounds 4a-e exhibited concentration-dependent cytotoxic effects at micromolar concentrations in MTT-dye reduction assay against a panel of human tumor cell lines, similar to those of starting chalcone 3. The tested agents led to concentration - dependent depletion of cellular GSH levels, whereby the effects of the chalcone prototype 3 and its Mannich base-derivatives were comparable. Conclusion: The highest chemosensitivity to the tested compounds was observed in BV- 173followed by SKW-3 and HL-60 cell lines.

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