Development of the glomerular mesangium

1988 ◽  
Vol 2 (1) ◽  
pp. 85-91 ◽  
Author(s):  
Nobuaki Yamanaka
Keyword(s):  
Glomerular Mesangium

Increased extracellular matrix synthesis and mRNA in mesangial cells grown in high-glucose medium

1991 ◽  
Vol 260 (2) ◽  
pp. F185-F191 ◽  
Author(s):  
S. H. Ayo ◽  
R. A. Radnik ◽  
W. F. Glass ◽  
J. A. Garoni ◽  
E. R. Rampt ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Protein Synthesis ◽  
High Glucose ◽  
Mesangial Cells ◽  
Matrix Proteins ◽  
Cell Protein ◽  
Enzyme Linked Immunosorbent Assay ◽  
Mrna Levels ◽  
Glomerular Mesangial Cells ◽  
Glomerular Mesangium

Nodular expansion of glomerular mesangium with increased amounts of extracellular matrix (ECM) material is pathognomic of diabetic nephropathy. The precise mechanisms involved in this accumulation are unknown. Recently, we reported using a solid-phase enzyme-linked immunosorbent assay (ELISA) technique that glomerular mesangial cells, the principal cell type residing in glomerular mesangium, accumulate 50–60% more fibronectin (FN), laminin (LM), and type IV collagen (T-IV) when cultured in medium containing high glucose (30 mM) (S. H. Ayo, R. A. Rodnik, J. Garoni, W. F. Glass II, and J. I. Kreiberg. Am. J. Pathol. 136: 1339-1348, 1990). ECM assembly is controlled by its rate of synthesis and degradation, as well as its binding and rate of incorporation into the ECM. To elucidate the mechanisms involved, pulse-chase experiments were designed to estimate ECM protein synthesis from the incorporation of Trans-35S [( 35S]methionine, [35S]cysteine) into immunoprecipitated FN, LM, and T-IV. mRNA levels were examined, and degradation rates were estimated from the disappearance of radioactivity from matrix proteins in mesangial cells previously incubated with Trans-35S. One week of growth in 30 mM glucose resulted in approximately 40–50% increase in the synthesis of all three matrix proteins compared with 10 mM glucose-grown cells. This was accompanied by a significant increase in the transcripts for all three matrix proteins (approximately twofold). The specific activity of the radiolabel in trichloroacetic acid-precipitable cell protein showed no difference between cells grown in 10 or 30 mM glucose, indicating that total protein synthesis was unchanged. After 1 wk, the rate of FN, LM, and T-IV collagen degradation was unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)

Changes in glomerular mesangium in kidneys with congenital nephrotic syndrome of the Finnish type

2009 ◽  
Vol 25 (5) ◽  
pp. 867-875 ◽  
Author(s):  
Anne Kaukinen ◽  
Arvi-Matti Kuusniemi ◽  
Heikki Helin ◽  
Hannu Jalanko
Keyword(s):  
Nephrotic Syndrome ◽  
Congenital Nephrotic Syndrome ◽  
Glomerular Mesangium ◽  
Finnish Type

scholarly journals Role of marrow-derived monocytes and mesangial cells in removal of immune complexes from renal glomeruli.

1979 ◽  
Vol 149 (1) ◽  
pp. 127-136 ◽  
Author(s):  
G E Striker ◽  
M Mannik ◽  
M Y Tung
Keyword(s):  
Immune Complexes ◽  
Marrow Transplantation ◽  
Mesangial Cells ◽  
Phagocytic Cells ◽  
Glomerular Mesangium ◽  
Dense Bodies ◽  
Mesangial Hypercellularity ◽  
Dense Deposits ◽  
X Irradiation

Phagocytosis of intravenously administered immune complexes by cells in the mesangium was investigated. The model used was that of exchange marrow transplantation between Chediak-Higashi (CH) mice and syngeneic partners after X-irradiation. This model was chosen since marrow-derived macrophages could be differentiated from resident mesangial cells by the presence of the characteristic giant lysosomes in phagocytic cells of the CH mice. Injected immune complexes were cleared normally and localized in the glomerular mesangium in CH or C57BL/6J mice receiving either C57BL/6J or CH marrow. C57BL/6J mice with CH marrow injected with immune complexes prepared with reduced and alkylated antibodies accumulated many cells within the mesangium that contained both giant lysosomes and electron dense deposits. Deposits were not found in cells with subplasmalemmal microfilaments and perpheral dense bodies. Conversely, the cells in the mesangium of CH mice with C57BL/6J marrow that contained electron dense deposits were devoid of giant lysosomes. Based on these observations, we concluded that (a) marrow-derived monocytes contribute to mesangial hypercellularity after deposition of immune complexes and (b) phagocytosis of immune complexes localized in the glomerular mesangium was by marrow-derived monocytes rather than by mesangial cells.

scholarly journals The glomerular mesangium in diabetes mellitus

1993 ◽  
Vol 43 (1) ◽  
pp. 109-113 ◽  
Author(s):  
Jeffrey I. Kreisberg ◽  
Suzanne H. Ayo
Keyword(s):  
Diabetes Mellitus ◽  
Glomerular Mesangium

Collagenofibrotic glomerulopathy in a young cat

2020 ◽  
Vol 8 (2) ◽  
pp. e001056
Author(s):  
Monika Hilbe ◽  
Manuela Schnyder ◽  
Udo Hetzel ◽  
Carole Schuppisser ◽  
Nicole Borel
Keyword(s):  
Angiostrongylus Vasorum ◽  
Asian Countries ◽  
Glomerular Mesangium ◽  
Pathological Mechanism ◽  
Collagen Iii ◽  
Subendothelial Space ◽  
Patent Infection

Collagenofibrotic glomerulopathy, also named collagen III glomerulopathy, is a rare glomerulopathy type caused by deposition of collagen III in the glomerular mesangium and subendothelial space. The aetiology of this entity is unknown and the pathological mechanism remains poorly understood. It is mostly seen in humans in Asian countries, especially in Japan. Collagenofibrotic glomerulopathy has been described in a macaque, in dogs, pigs and in a cat, published as renal glomerular fibrosis. Here, the authors present a case of collagenofibrotic glomerulopathy in a young European domestic shorthair cat, which developed a severe hypoproteinaemia, hypoalbuminaemia and proteinuria and showed a concurrent natural non-patent infection with the canid lungworm Angiostrongylus vasorum.

The glomerular mesangium: Kinetics using radiolabeled ferritin and the effects of aggregated IgG

1984 ◽  
Vol 33 (1) ◽  
pp. 80-86 ◽  
Author(s):  
Heitor F. Borges ◽  
Carl Goldstein ◽  
Myungjae Kim ◽  
Alfred F. Michael
Keyword(s):  
Glomerular Mesangium

scholarly journals Elastic fiber proteins in the glomerular mesangium in vivo and in cell culture

2000 ◽  
Vol 58 (4) ◽  
pp. 1588-1602 ◽  
Author(s):  
R. Bernd Sterzel ◽  
Andrea Hartner ◽  
Ursula Schlötzer-Schrehardt ◽  
Susanne Voit ◽  
Birgit Hausknecht ◽  
...  
Keyword(s):  
Cell Culture ◽  
Elastic Fiber ◽  
Glomerular Mesangium ◽  
Fiber Proteins

scholarly journals Tbx18 is essential for normal development of vasculature network and glomerular mesangium in the mammalian kidney

2014 ◽  
Vol 391 (1) ◽  
pp. 17-31 ◽  
Author(s):  
Jinshu Xu ◽  
Xuguang Nie ◽  
Xiaoqiang Cai ◽  
Chen-Leng Cai ◽  
Pin-Xian Xu
Keyword(s):  
Normal Development ◽  
Mammalian Kidney ◽  
Glomerular Mesangium

The Glomerular Mesangium

1981 ◽  
Vol 11 (s1) ◽  
pp. 83-87
Author(s):  
A. F. Michael
Keyword(s):  
Glomerular Mesangium
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