Potentiation of the damaging action of free fatty acids on brain synaptosomes by vitamin E deficiency

1986 ◽  
Vol 102 (5) ◽  
pp. 1520-1522
Author(s):  
V. I. Skrypin ◽  
V. I. Brusovanik ◽  
L. M. Dzhaparidze ◽  
A. N. Erin ◽  
A. A. Selishcheva ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Vitamin E ◽  
Free Fatty Acids ◽  
Vitamin E Deficiency ◽  
Brain Synaptosomes

scholarly journals The effects of vitamin E deficiency on the total fatty acids and the phospholipid fatty acids of rat tissues

1969 ◽  
Vol 23 (2) ◽  
pp. 289-295 ◽  
Author(s):  
D. J. W. Lee ◽  
M. McC. Barnes
Keyword(s):  
Fatty Acids ◽  
Vitamin E ◽  
Total Phospholipid ◽  
Rat Tissues ◽  
Vitamin E Deficiency ◽  
Deficient Diet ◽  
Acid Deficiency ◽  
Total Fatty Acids ◽  
Fatty Acid Deficiency ◽  
Kidney Liver

1. A vitamin E-low diet containing 7% stripped lard was given to hooded rats for periods up to 14 months. Control rats were given the same diet with a vitamin E supplement (I i.u./rat per day).2. No consistent pattern of changes was found in the total fatty acids of testis, lung, spleen, pancreas, heart, kidney, liver, brain, skeletal muscle and small intestine from rats given the deficient diet for 5, 6 or 7 months when compared with control rats.3. The fatty acids of the total phospholipid from the same tissues were examined after 4, 5, 8 or 14 months. In the rats deficient in vitamin E the polyunsaturated fatty acids of the linoleic series (ω6) decreased, except for 20:4ω6, which in some tissues tended to increase. After 14 months there were considerable decreases in the percentages of all the ω6 series including 20:4ω6 with increases in the percentages of 18:1ω9 and 20:3ω9 the pattern was similar to that found in essential fatty acid deficiency.

scholarly journals Application of Sebum Lipidomics to Biomarkers Discovery in Neurodegenerative Diseases

Metabolites ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 819
Author(s):  
Stefania Briganti ◽  
Mauro Truglio ◽  
Antonella Angiolillo ◽  
Salvatore Lombardo ◽  
Deborah Leccese ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Vitamin E ◽  
Observational Study ◽  
Neurodegenerative Diseases ◽  
Free Fatty Acids ◽  
Healthy Subjects ◽  
Skin Surface ◽  
Biosynthetic Pathways ◽  
Simultaneous Component Analysis ◽  
Lipid Species

Lipidomics is strategic in the discovery of biomarkers of neurodegenerative diseases (NDDs). The skin surface lipidome bears the potential to provide biomarker candidates in the detection of pathological processes occurring in distal organs. We investigated the sebum composition to search diagnostic and, possibly, prognostic, biomarkers of Alzheimer’s disease (AD) and Parkinson’s disease (PD). The observational study included 64 subjects: 20 characterized as “probable AD with documented decline”, 20 as “clinically established PD”, and 24 healthy subjects (HS) of comparable age. The analysis of sebum by GCMS and TLC retrieved the amounts (µg) of 41 free fatty acids (FFAs), 7 fatty alcohols (FOHs), vitamin E, cholesterol, squalene, and total triglycerides (TGs) and wax esters (WEs). Distributions of sebum lipids in NDDs and healthy conditions were investigated with multivariate ANOVA-simultaneous component analysis (ASCA). The deranged sebum composition associated with the PD group showed incretion of most composing lipids compared to HS, whereas only two lipid species (vitamin E and FOH14:0) were discriminant of AD samples and presented lower levels than HS sebum. Thus, sebum lipid biosynthetic pathways are differently affected in PD and AD. The characteristic sebum bio-signatures detected support the value of sebum lipidomics in the biomarkers search in NDDs.

scholarly journals Effects of vitamin E deficiency on total polyunsaturated fatty acids in rats and chicks

1967 ◽  
Vol 21 (1) ◽  
pp. 217-224 ◽  
Author(s):  
J. Bunyan ◽  
A. T. Diplock ◽  
J. Green
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid ◽  
Vitamin E ◽  
Cod Liver Oil ◽  
Pufa Content ◽  
Specific Nature ◽  
Vitamin E Deficiency ◽  
Exudative Diathesis ◽  
Total Pufa

1. The total polyunsaturated fatty acid (PUFA) content of tissues of vitamin E-deficient rats and chicks has been measured by the lipoxidase method.2. Vitamin E deficiency did not depress total PUFA in rat liver, kidney, heart, spleen, brain, adrenal and adipose tissue during experimental periods up to 13 months.3. Liver PUFA was not depressed by deficiency of vitamin E and selenium in rats at 9 weeks or 8 months of age.4. Rats given a muscular dystrophy-producing diet (containing oxidized cod-liver oil) showed a severe depletion of PUFA in muscle, but not in kidney or adipose tissue.5. Exudative diathesis induced in chicks by a deficiency of vitamin E and Se did not depress liver PUFA.6. It is considered that in vitamin E deficiency there is no general decrease in PUFA due to peroxidative loss. Changes of a more specific nature occur, as found by other workers.

scholarly journals Vitamin E Profiles and Triacylglycerol Molecular Species of Colored Rice Bran Cultivars at Different Degree of Milling

2013 ◽  
Vol 2 (6) ◽  
pp. 106
Author(s):  
Hiromi Yoshida ◽  
Mika Kanamori ◽  
Naoko Yoshida ◽  
Yuka Sakamoto ◽  
Isoko Kuriyama ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Vitamin E ◽  
Free Fatty Acids ◽  
Rice Bran ◽  
Molecular Species ◽  
Alpha Tocopherol ◽  
Positive Health ◽  
Degree Of Milling ◽  
Triacylglycerol Molecular Species ◽  
Colored Rice

The objective of this study was to evalute the tocochromanol distributions, lipid components and molecular species of triacylglycerols (TAG) in three colored rice bran cultivars. The dominant tocochromanol were gama-tocotrienol, alpha-tocopherol and alpha-tocotrienol with smaller amounts of gama-tocopherol, delta-tocopherol and delta-tocotrienol. These lipids comprised mainly TAG (78.0-81.6 wt%), free fatty acids (FFA: 5.6-8.8 wt%), and phospholipids (PL: 6.3-7.0 wt%), while other components were present in minor proportions (0.4-2.3 wt%). Sixteen different TAG molecular species were detected and quantified by successive applications of AgNO<sub>3</sub>-TLC and GC. The major TAG molecular species were SM<sub>2 </sub>(6.1-9.8%), S<sub>2</sub>D (4.8-7.3%)?M<sub>3</sub> (16.4-18.7%), SMD (6.2-9.2%), SD<sub>2</sub> (6.5-9.5%), SMT (6.3-7.7%), M<sub>2</sub>D (12.3-15.5%.), MD<sub>2</sub> (8.4-10.4%), SDT (4.3-5.4%) and D<sub>3</sub> (10.2-15.2%) (where S, M, D, and T denote saturated FA, monoene, diene, and triene, respectively). The results showed that colored rice bran lipids contain large amounts of nutraceutical with proven positive health effects.

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