On changes in the structure of water due to its contact with a solid phase. II. IR-spectroscopy studies

1992 ◽  
Vol 62 (6) ◽  
pp. 627-632
Author(s):  
P. P. Olodovskii
2015 ◽  
Vol 89 (7) ◽  
pp. 1244-1247 ◽  
Author(s):  
E. A. Masimov ◽  
B. G. Pashayev ◽  
H. Sh. Hasanov ◽  
N. H. Hasanov

Crystals ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 760
Author(s):  
Sae Ishihara ◽  
Yusuke Hattori ◽  
Makoto Otsuka ◽  
Tetsuo Sasaki

Cocrystallisation can enhance the solubility and bioavailability of active pharmaceutical ingredients (APIs); this method may be applied to improve the availability of materials that were previously considered unsuitable. Terahertz (THz) spectroscopy provides clear, substance-specific fingerprint spectra; the transparency of the THz wave allows us to probe inside a sample to identify medicinal materials. In this study, THz and infrared (IR) spectroscopy were used to characterise cocrystallisation in solid-phase reactions between ibuprofen and nicotinamide. Multivariate curve resolution with alternating least squares (MCR-ALS) was applied to both time-dependent THz and IR spectra to identify the intermolecular interactions between these cocrystallising species. The analytical results revealed cocrystal formation through a two-step reaction, in which the steps were dominated by thermal energy and water vapour, respectively. We infer that the presence of water molecules significantly lowered the activation energy of cocrystal formation.


2016 ◽  
Vol 231 ◽  
pp. S93 ◽  
Author(s):  
Mara Grube ◽  
Karlis Shvirksts ◽  
Dominyka Dapkute ◽  
Marija Matulionyte ◽  
Elina Zandberga ◽  
...  

2001 ◽  
Vol 242 (1) ◽  
pp. 133-140 ◽  
Author(s):  
Hiromi Kitano ◽  
Ken Ichikawa ◽  
Mitsuhiro Fukuda ◽  
Akira Mochizuki ◽  
Masaru Tanaka

1985 ◽  
Vol 5-6 ◽  
pp. 311-322 ◽  
Author(s):  
S.R. Loehr ◽  
Allan J. Bruce ◽  
R. Mossadegh ◽  
Robert H. Doremus ◽  
Cornelius T. Moynihan

2008 ◽  
Vol 863 (2) ◽  
pp. 242-248 ◽  
Author(s):  
Sébastien Gagné ◽  
Julie Laterreur ◽  
Louiza Mahrouche ◽  
Dan Sørensen ◽  
Jacques Yves Gauthier ◽  
...  

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