Investigation of nucleophilic aromatic substitution under high pressure

1965 ◽  
Vol 14 (7) ◽  
pp. 1154-1158
Author(s):  
N. I. Prokhorova ◽  
M. G. Gonikberg
Keyword(s):  
High Pressure ◽  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution

Nucleophilic aromatic substitution of heterocycles using a high-temperature and high-pressure flow reactor

2016 ◽  
Vol 57 (9) ◽  
pp. 1035-1039 ◽  
Author(s):  
Manwika Charaschanya ◽  
Andrew R. Bogdan ◽  
Ying Wang ◽  
Stevan W. Djuric
Keyword(s):  
High Pressure ◽  
High Temperature ◽  
Flow Reactor ◽  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Pressure Flow

scholarly journals Machine learning meets mechanistic modelling for accurate prediction of experimental activation energies

2021 ◽  
Author(s):  
Kjell Jorner ◽  
Tore Brinck ◽  
Per-Ola Norrby ◽  
David Buttar
Keyword(s):  
Machine Learning ◽  
Activation Energies ◽  
Accurate Prediction ◽  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Mechanistic Modelling

Hybrid reactivity models, combining mechanistic calculations and machine learning with descriptors, are used to predict barriers for nucleophilic aromatic substitution.

Enantioselective Nucleophilic Aromatic Substitution Reaction of Azlactones to Synthesize Quaternary α-Amino Acid Derivatives

Synlett ◽  
2020 ◽  
Author(s):  
Xiaohua Liu ◽  
Yi Li ◽  
Hao Pan ◽  
Wang-Yuren Li ◽  
Xiaoming Feng
Keyword(s):  
Hydrogen Bonding ◽  
Charge Transfer ◽  
Amino Acid ◽  
Substitution Reaction ◽  
Nucleophilic Aromatic Substitution ◽  
Amino Acid Derivatives ◽  
Amino Acid Esters ◽  
Aromatic Substitution ◽  
Charge Transfer Interaction ◽  
Acid Esters

AbstractAn asymmetric organocatalytic nucleophilic aromatic substitution reaction of azlactones with electron-deficient aryls was established. A variety of α-aryl α-alkyl α-amino acid esters and peptides were obtained in decent yields and stereoselectivities. A new bifunctional catalytic mode involving charge-transfer interaction and hydrogen bonding is proposed to explain the enantioselectivity.

Nucleophilic aromatic substitution using Et3SiH/cat. t-Bu-P4 as a system for nucleophile activation

2007 ◽  
pp. 2264 ◽  
Author(s):  
Masahiro Ueno ◽  
Misato Yonemoto ◽  
Masahiro Hashimoto ◽  
Andrew E. H. Wheatley ◽  
Hiroshi Naka ◽  
...  
Keyword(s):  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Nucleophile Activation

Novel One-Pot Synthesis of Xanthones via Sequential Fluoride Ion-Promoted Fries-Type Rearrangement and Nucleophilic Aromatic Substitution

Synlett ◽  
2013 ◽  
Vol 24 (19) ◽  
pp. 2575-2580 ◽  
Author(s):  
Takashi Matsumoto ◽  
Yuuki Fujimoto ◽  
Ryohei Itakura ◽  
Hiroki Hoshi ◽  
Hikaru Yanai ◽  
...  
Keyword(s):  
Nucleophilic Aromatic Substitution ◽  
Fluoride Ion ◽  
Aromatic Substitution ◽  
One Pot ◽  
One Pot Synthesis
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