Regeneration of the liver in young rats after allyl alcohol-induced injury to the periportal zones

T. P. Beketova; K. Lapis; V. V. Korolev; L. Kovacs

doi:10.1007/bf00844562

Regeneration of the liver in young rats after allyl alcohol-induced injury to the periportal zones

Bulletin of Experimental Biology and Medicine ◽

10.1007/bf00844562 ◽

1980 ◽

Vol 90 (2) ◽

pp. 1152-1156

Author(s):

T. P. Beketova ◽

K. Lapis ◽

V. V. Korolev ◽

L. Kovacs

Keyword(s):

Allyl Alcohol ◽

Regeneration Of The Liver ◽

Young Rats

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The importance of CREB phosphorylation by PKA, CaMK and MAPK for olfactory learning in young rats

Neuroscience Research ◽

10.1016/s0168-0102(00)81442-x ◽

2000 ◽

Vol 38 ◽

pp. S99

Author(s):

J Zhang

Keyword(s):

Olfactory Learning ◽

Creb Phosphorylation ◽

Young Rats

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On the Fibrinolytic System in Aged Rats, and Its Reactivity to Endotoxin and Cytokines

Thrombosis and Haemostasis ◽

10.1055/s-0038-1648525 ◽

1992 ◽

Vol 67 (06) ◽

pp. 697-701 ◽

Cited By ~ 6

Author(s):

J J Emeis ◽

A Brouwer ◽

R J Barelds ◽

M A Horan ◽

S K Durham ◽

...

Keyword(s):

Plasminogen Activator ◽

Fibrinolytic Activity ◽

Fibrinolytic System ◽

Tissue Type ◽

High Dose ◽

Base Line ◽

Aged Rats ◽

Tissue Type Plasminogen Activator ◽

Young Rats ◽

Type Plasminogen Activator

SummaryAged rats are more susceptible to endotoxin-induced effects, including microthrombosis and platelet aggregation, than are young rats. To investigate whether changes in the fibrinolytic system might be involved, we investigated the fibrinolytic activity in plasma euglobulin fractions and tissues (lung and heart) of young (6-months old) and aged (24-months old) rats under baseline conditions and after challenge with endotoxin. Aged rats had lower plasma levels of tissue-type plasminogen activator (t-PA) and of urokinase-type PA (u-PA) activity. PA inhibitor (PAI) activity was higher in the plasma of aged rats, as was t-PA activity in lung and heart.Rats were treated with either a low dose (1 μg/kg) or a high dose (10 mg/kg) of endotoxin. Both treatments induced a transient phase of increased blood fibrinolytic activity, as evidenced by higher levels of tissue-type plasminogen activator (t-PA) activity and decreased levels of PA inhibitor (PAI) activity. Over time, the fibrinolytic activity decreased, probably due to increased levels of PA inhibitor.Both the early increase in t-PA activity, and the subsequent increase in PAI activity, were more pronounced in the aged rats, as compared with the younger rats, after the high dose of endotoxin. The aged rats also responded to an injection of interleukin-1β or tumor necrosis factor-α with a larger increase of PAI activity than did the younger rats.Together the data suggest that, compared to young rats, aged rats have a decreased base-line plasma fibrinolytic activity, while their fibrinolytic system is more responsive to challenge by endotoxin and cytokines.

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