Action of tyramine on the spinal afferent link of pressor reflexes

1986 ◽  
Vol 102 (3) ◽  
pp. 1169-1172
Author(s):  
G. O. Karagulova ◽  
G. I. Bochkina ◽  
E. V. Lukoshkova
Keyword(s):  
Pressor Reflexes

Inhibition of the spinal efferent component of pressor reflexes by noradrenalin

1986 ◽  
Vol 101 (4) ◽  
pp. 399-402
Author(s):  
G. O. Karagulova ◽  
G. I. Bochkina ◽  
T. B. Shuvalova ◽  
E. V. Lukoshkova
Keyword(s):  
Pressor Reflexes

Interaction between carotid sinus baroreceptor and aortic nerve pressor reflexes in the dog

1979 ◽  
Vol 237 (6) ◽  
pp. H662-H667
Author(s):  
J. E. Kendrick ◽  
G. L. Matson
Keyword(s):  
Electrical Stimulation ◽  
Carotid Sinus ◽  
Pressor Response ◽  
Low Frequency ◽  
Carotid Sinus Nerve ◽  
Constant Frequency ◽  
Aortic Nerve ◽  
Frequency Stimulation ◽  
Pressor Reflexes ◽  
Stimulation Of

In dogs anesthetized with morphine-chloralose, strong, low-frequency (2 Hz) electrical stimulation of the aortic nerve (AN) causes pressure in the perfused hindlimbs to rise. This pressor response is followed by a large depressor phase upon cessation of stimulation. Simultaneous stimulation of the ipsilateral carotid sinus nerve (CSN) with intermittent trains of stimuli enhanced the AN pressor response by 113%. Similar stimulation of the contralateral CSN had little effect on the AN pressor response. Constant-frequency stimulation of the ipsilateral CSN also failed to enhance this response. Possible mechanisms of the interaction between these antagonistic reflexes were investigated. The results suggest that the augmentation of the AN pressor response results from a central neuronal interaction between these antagonistic reflexes.

Orthostatic hypertension: when pressor reflexes overcompensate

2006 ◽  
Vol 2 (8) ◽  
pp. 424-431 ◽  
Author(s):  
Joshua Fessel ◽  
David Robertson
Keyword(s):  
Orthostatic Hypertension ◽  
Pressor Reflexes

Potentiation by Naloxone of Pressor Reflexes

1982 ◽  
Vol 26 (5) ◽  
pp. 263-264
Author(s):  
J.-L. MONTASTRUC ◽  
P. MONTASTRUC ◽  
F. MORALES-OLIVAS
Keyword(s):  
Pressor Reflexes

scholarly journals Role of TRPV1 in acupuncture modulation of reflex excitatory cardiovascular responses

2018 ◽  
Vol 314 (5) ◽  
pp. R655-R666 ◽  
Author(s):  
Zhi-Ling Guo ◽  
Liang-Wu Fu ◽  
Hou-Fen Su ◽  
Stephanie C. Tjen-A-Looi ◽  
John C. Longhurst
Keyword(s):  
Intracellular Signaling ◽  
Intrathecal Injection ◽  
Sensory Nerve ◽  
Cardiovascular Responses ◽  
Nerve Fibers ◽  
Cardiovascular Reflexes ◽  
Transient Receptor Potential Vanilloid ◽  
Group Iii ◽  
Afferent Nerves ◽  
Pressor Reflexes

We have shown that acupuncture, including manual and electroacupuncture (MA and EA), at the P5–6 acupoints stimulates afferent fibers in the median nerve (MN) to modulate sympathoexcitatory cardiovascular reflexes through central regulation of autonomic function. However, the mechanisms underlying acupuncture activation of these sensory afferent nerves and their cell bodies in the dorsal root ganglia (DRG) are unclear. Transient receptor potential vanilloid type 1 (TRPV1) is present in sensory nerve fibers distributed in the general region of acupoints like ST36 and BL 40 located in the hindlimb. However, the contribution of TRPV1 to activation of sensory nerves by acupuncture, leading to modulation of pressor responses, has not been studied. We hypothesized that TRPV1 participates in acupuncture’s activation of sensory afferents and their associated cell bodies in the DRG to modulate pressor reflexes. Local injection of iodoresiniferatoxin (Iodo-RTX; a selective TRPV1 antagonist), but not 5% DMSO (vehicle), into the P6 acupoint on the forelimb reversed the MA’s inhibition of pressor reflexes induced by gastric distension (GD). Conversely, inhibition of GD-induced sympathoexcitatory responses by EA at P5–6 was unchanged after administration of Iodo-RTX into P5–6. Single-unit activity of Group III or IV bimodal afferents sensitive to both mechanical and capsaicin stimuli responded to MA stimulation at P6. MA-evoked activity was attenuated significantly ( P < 0.05) by local administration of Iodo-RTX ( n = 12) but not by 5% DMSO ( n = 12) into the region of the P6 acupoint in rats. Administration of Iodo-RTX into P5–6 did not reduce bimodal afferent activity evoked by EA stimulation ( n = 8). Finally, MA at P6 and EA at P5–6 induced phosphorylation of extracellular signal-regulated kinases (ERK; an intracellular signaling messenger involved in cellular excitation) in DRG neurons located at C7–8 spinal levels receiving MN inputs. After TRPV1 was knocked down in the DRG at these spinal levels with intrathecal injection of TRPV1-siRNA, expression of phosphorylated ERK in the DRG neuron was reduced in MA-treated, but not EA-treated animals. These data suggest that TRPV1 in Group III and IV bimodal sensory afferent nerves contributes to acupuncture inhibition of reflex increases in blood pressure and specifically plays an important role during MA but not EA.

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