Hepatotropic action of benzobamil in CCL4 poisoning

A. I. Vengerovskii; I. M. Sedykh; A. S. Saratikov

doi:10.1007/bf00842195

Accelerated liver recovery after acute CCl4 poisoning in rats treated with sodium phthalhydrazide

International Immunopharmacology ◽

10.1016/j.intimp.2019.106124 ◽

2020 ◽

Vol 80 ◽

pp. 106124

Author(s):

Irina G. Danilova ◽

Zlata A. Shafigullina ◽

Irina F. Gette ◽

Valentin G. Sencov ◽

Svetlana Yu. Medvedeva ◽

...

Keyword(s):

Ccl4 Poisoning

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Potassium conserving phenomenon during potassium deficiency in rats and impairment by chronic CCL4-poisoning

Gastroenterologia Japonica ◽

10.1007/bf02801507 ◽

1967 ◽

Vol 2 (2) ◽

pp. 138-138

Author(s):

H. Maezawa ◽

Y. Ito ◽

K. Ono ◽

S. Hosaki ◽

K. Ohta

Keyword(s):

Potassium Deficiency ◽

Ccl4 Poisoning

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Pharmacology and toxicology of carbon tetrachloride in the sheep. IV. Reduction and augmentation of toxicity by selenium

Australian Journal of Agricultural Research ◽

10.1071/ar9670667 ◽

1967 ◽

Vol 18 (4) ◽

pp. 667

Author(s):

AC Kondos ◽

GL McClymont

Keyword(s):

Carbon Tetrachloride ◽

Oral Administration ◽

Fasciola Hepatica ◽

Clinical Signs ◽

Field Tests ◽

High Protein Diet ◽

Intramuscular Dose ◽

History Of ◽

Ccl4 Poisoning ◽

Oral Doses

Susceptibility of sheep to toxic effects of carbon tetrachloride (CCl4) was assessed by determining the increase in plasma levels of isocitric dehydrogenase (ICD) and glutamic transaminase (GOT) and by other criteria. Susceptibility was increased by oral administration of 1 mg of selenium (Se) as sodium selenite plus 100 i.u. of tocopherol acetate on alternate days for 120 days, 2 mg Se per day for 21 days, and 6 mg Se per day for 6 days, before dosing with CCl4. Susceptibility was reduced by smaller total amounts of Se, and by oral doses of 6 mg Se per day for 3 days, a single oral or intramuscular dose of 5 or 12 mg c. 20 hr, or 5 or 12 mg orally 10–20 min, before dosing with CCl4. One 5 mg dose at 20 hr and a second 20 min before CCl4 was more effective than either alone. Sheep from two different sources differed considerably in their susceptibility to CCl4. In the more susceptible sheep Se administration reduced susceptibility to a level comparable with that shown by the naturally resistant animals. Administration of Se to sheep dosed with CCl4 and then given a high-protein diet resulted in lower GOT levels, milder clinical signs, and a great reduction in mortality. In field tests on properties with a recent history of CCl4 poisoning, oral administration of 5 mg Se about 20 min before CCl4 significantly reduced susceptibility. Administration of Se to fluke-infested sheep did not protect the liver fluke (Fasciola hepatica) against CCl4.

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Carbon tetrachloride poisoning in sheep: Effect upon the serum E260 value and plasma volume

Australian Journal of Agricultural Research ◽

10.1071/ar9621073 ◽

1962 ◽

Vol 13 (6) ◽

pp. 1073 ◽

Cited By ~ 1

Author(s):

CH Gallagher

Keyword(s):

Carbon Tetrachloride ◽

No Value ◽

Plasma Volume ◽

Stomach Tube ◽

Ccl4 Poisoning ◽

The Mean ◽

The One ◽

Diagnostic Criterion ◽

Very High

Serum E260 values were determined at intervals in sheep which were given 50 ml carbon tetrachloride (CCl4) by stomach tube into the rumen, and in untreated sheep. After administration of the drug, the mean E260 value fell initially, being minimal at 3 hr. At this time, the circulating plasma volume had increased by one-fifth, and it is considered that this dilution factor largely explained the fall. The group mean for non-fatal cases rose above the pre-administration level at 7 hr, then returned to it by 24 hr. However, in the one sheep that died from CCl4 poisoning, the serum E260 value remained very high until death at 46 hr. In view of the significant variations in serum E260 values between untreated sheep, and the significant random variations in serum E260 values between times of bleeding such sheep, it is concluded that the determination of serum E260 values at isolated times in individual sheep is of no value as a diagnostic criterion of CCl4 poisoning.

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Inhibition by aldehydes as a possible further mechanism for glucose-6-phosphatase inactivation during CCl4-poisoning

Chemico-Biological Interactions ◽

10.1016/0009-2797(77)90044-8 ◽

1977 ◽

Vol 19 (1) ◽

pp. 91-100 ◽

Cited By ~ 14

Author(s):

G. Bertone ◽

M.U. Dianzani

Keyword(s):

Ccl4 Poisoning

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Corrigendum - Pharmacology and toxicology of carbon tetrachloride in the sheep. IV. Reduction and augmentation of toxicity by selenium.

Australian Journal of Agricultural Research ◽

10.1071/ar9670667c ◽

1967 ◽

Vol 18 (4) ◽

pp. 667

Author(s):

AC Kondos ◽

GL McClymont

Keyword(s):

Carbon Tetrachloride ◽

Oral Administration ◽

Fasciola Hepatica ◽

Clinical Signs ◽

Field Tests ◽

High Protein Diet ◽

Intramuscular Dose ◽

History Of ◽

Ccl4 Poisoning ◽

Oral Doses

Susceptibility of sheep to toxic effects of carbon tetrachloride (CCl4) was assessed by determining the increase in plasma levels of isocitric dehydrogenase (ICD) and glutamic transaminase (GOT) and by other criteria. Susceptibility was increased by oral administration of 1 mg of selenium (Se) as sodium selenite plus 100 i.u. of tocopherol acetate on alternate days for 120 days, 2 mg Se per day for 21 days, and 6 mg Se per day for 6 days, before dosing with CCl4. Susceptibility was reduced by smaller total amounts of Se, and by oral doses of 6 mg Se per day for 3 days, a single oral or intramuscular dose of 5 or 12 mg c. 20 hr, or 5 or 12 mg orally 10–20 min, before dosing with CCl4. One 5 mg dose at 20 hr and a second 20 min before CCl4 was more effective than either alone. Sheep from two different sources differed considerably in their susceptibility to CCl4. In the more susceptible sheep Se administration reduced susceptibility to a level comparable with that shown by the naturally resistant animals. Administration of Se to sheep dosed with CCl4 and then given a high-protein diet resulted in lower GOT levels, milder clinical signs, and a great reduction in mortality. In field tests on properties with a recent history of CCl4 poisoning, oral administration of 5 mg Se about 20 min before CCl4 significantly reduced susceptibility. Administration of Se to fluke-infested sheep did not protect the liver fluke (Fasciola hepatica) against CCl4.

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