Free calcium concentration in brain nerve endings of spontaneously hypertensive rats

1987 ◽  
Vol 103 (5) ◽  
pp. 609-612 ◽  
Author(s):  
S. N. Orlov ◽  
N. I. Pokudin ◽  
G. M. Kravtsov ◽  
Yu. V. Postnov ◽  
I. M. Okun' ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Calcium Concentration ◽  
Nerve Endings ◽  
Free Calcium ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Free Calcium Concentration

Cytoplasmic Free [Ca2+] is Increased in the Platelets of Spontaneously Hypertensive Rats and Essential Hypertensive Patients

1985 ◽  
Vol 68 (2) ◽  
pp. 179-184 ◽  
Author(s):  
Giacomo Bruschi ◽  
Maria E. Bruschi ◽  
Maurizio Caroppo ◽  
Guido Orlandini ◽  
Marco Spaggiari ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Calcium Concentration ◽  
Free Calcium ◽  
Cytoplasmic Calcium ◽  
Hypertensive Rats ◽  
Hypertensive Patients ◽  
Spontaneously Hypertensive ◽  
Human Control ◽  
Free Calcium Concentration ◽  
Wistar Kyoto

1. The cytoplasmic free calcium concentration ([Ca2+]i) was assessed with the fluorescent dye Quin 2 in platelets and lymphocytes of spontaneously hypertensive rats (SHR), normotensive Wistar—Kyoto rats (WKY), essential hypertensive patients (EHP) and normotensive human control subjects (NCS). 2. [Ca2+]i was significantly higher in the platelets of 8- and 20-week-old SHR in comparison with WKY. However, no difference was evident after weaning. Changes of cellular calcium in hypertensive rats apparently evolved simultaneously with the development of high arterial pressure. 3. [Ca2+]i was significantly higher in platelets of EHP than in NCS. 4. In lymphocytes of SHR, [Ca2+]i was not different from WKY at 4 and 8 weeks, but was increased at 14 weeks and at older ages. In EHP, intralymphocytic [Ca2+] was only modestly higher than in controls. On the whole, the results suggest that control of cytoplasmic calcium in these blood cells is similarly affected in human and animal models of primary hypertension.

Cytoplasmic free [Ca2+] is not increased in the platelets of deoxycorticosterone–salt and spontaneously hypertensive rats

1986 ◽  
Vol 71 (1) ◽  
pp. 121-123 ◽  
Author(s):  
Koh-Ichi Murakawa ◽  
Yoshiharu Kanayama ◽  
Masakazu Kohno ◽  
Takahiko Kawarabayashi ◽  
Kenichi Yasunari ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Free Calcium ◽  
Sprague Dawley ◽  
Hypertensive Rats ◽  
Acetoxymethyl Ester ◽  
Spontaneously Hypertensive ◽  
Sprague Dawley Rats ◽  
Significant Difference ◽  
Free Calcium Concentration ◽  
Wistar Kyoto

1. The cytoplasmic free calcium concentration ([Ca2+]i) in the platelets of spontaneously hypertensive rats (SHR), Wistar–Kyoto rats (WKY), deoxycorticosterone–salt hypertensive rats (DOC) and normotensive Sprague–Dawley rats (SD) was measured with the fluorescent dye, quin-2-tetra-acetoxymethyl ester. 2. No significant difference in platelet [Ca2+]i was found between SHR and WKY or between DOC and SD rats. 3. No correlations were found between systolic blood pressure and [Ca2+]i. 4. These results suggest that the elevation of platelet [Ca2+]i does not necessarily accompany hypertension in rats.

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