Carbonic anhydrase III ? A marker of human salivary gland myoepithelial cells

1991 ◽  
Vol 111 (3) ◽  
pp. 405-406
Author(s):  
N. Sh. Shamsutdinov ◽  
R. I. Islamov ◽  
V. V. Valuillin
Keyword(s):  
Salivary Gland ◽  
Carbonic Anhydrase ◽  
Myoepithelial Cells ◽  
Human Salivary Gland ◽  
Carbonic Anhydrase Iii

scholarly journals Induction of other differentiation stages in neoplastic epithelial duct and myoepithelial cells from the human salivary gland grown in athymic nude mice

Cancer ◽  
1985 ◽  
Vol 55 (11) ◽  
pp. 2575-2583 ◽  
Author(s):  
Yoshio Hayashi ◽  
Tetsuo Yanagawa ◽  
Hideo Yoshida ◽  
Yoshiaki Yura ◽  
Toshiharu Nitta ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Nude Mice ◽  
Myoepithelial Cells ◽  
Athymic Nude Mice ◽  
Human Salivary Gland

scholarly journals Carbonic anhydrase III: a new histochemical marker for myoepithelial cells.

1987 ◽  
Vol 35 (6) ◽  
pp. 683-686 ◽  
Author(s):  
H K Väänänen ◽  
H Autio-Harmainen
Keyword(s):  
Skeletal Muscle ◽  
Carbonic Anhydrase ◽  
Myoepithelial Cells ◽  
Major Protein ◽  
Human Uterus ◽  
Cell Type ◽  
Epithelial Cell Type ◽  
Tissue Sections ◽  
Carbonic Anhydrase Iii ◽  
Histochemical Marker

Carbonic anhydrase III, a major protein of red skeletal muscle, was localized immunohistochemically in smooth muscle cells of human uterus and in myoepithelial cells of mammary and prostate glands. The presence of this antigen in myoepithelial cells could be used to detect these not easily recognizable cells in paraffin-embedded tissue sections. Some epithelial cells of larger mammary ducts revealed occasional strongly positive cells. These cells may represent a new epithelial cell type transitional between myoepithelium and ductal epithelium.

scholarly journals p63 Is Expressed in Basal and Myoepithelial Cells of Human Normal and Tumor Salivary Gland Tissues

2003 ◽  
Vol 51 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Hadi Bilal ◽  
Adriana Handra-Luca ◽  
Jacques-Charles Bertrand ◽  
Pierre J. Fouret
Keyword(s):  
Salivary Gland ◽  
Myoepithelial Cells ◽  
Salivary Gland Tumors ◽  
Basal Cells ◽  
Squamous Cells ◽  
Human Salivary Gland ◽  
Duct Cells ◽  
Normal Human ◽  
Luminal Cells ◽  
Tumor Types

p63 is essential for epithelial cell survival and may function as an oncogene. We examined by immunohistochemistry p63 expression in human normal and tumor salivary gland tissues. In normal salivary glands, p63 was expressed in the nuclei of myoepithelial and basal duct cells. Among 68 representative salivary gland tumors, 63 displayed p63 reactivity. In all tumor types differentiated towards luminal and myoepithelial lineages (pleomorphic adenomas, basal cell adenomas, adenoid cystic carcinomas, and epithelial-myoepithelial carcinomas), p63 was expressed in myoepithelial cells, whereas luminal cells were always negative. Similarly, in mucoepidermoid carcinomas, basal, intermediate, and squamous cells expressed p63, in contrast to luminal mucous cells. p63 reactivity was also restricted to basal cells in Warthin tumors and oncocytomas. Myoepitheliomas and myoepithelial carcinomas all expressed p63. The only five negative tumors were three of four acinar cell carcinomas and two of three adenocarcinomas. In conclusion, p63 is expressed in the nuclei of normal human salivary gland myoepithelial and basal duct cells. p63 expression is retained in the modified myoepithelial and basal cells of human salivary gland tumors, which suggests a role for p63 in oncogenesis of these complex tumors.

scholarly journals AB0133 INCREASED SOLUBLE SEMAPHORIN 4D/CD100 IN THE PLASMA OF SJÖGREN’S SYNDROME AND ITS EFFECTS ON HUMAN SALIVARY GLAND CELL AND CD4+ T CELL

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1367.1-1367
Author(s):  
S. E. Kang ◽  
S. U. Kim ◽  
R. H. Kim ◽  
H. J. Yoo ◽  
Y. J. Lee ◽  
...  
Keyword(s):  
T Cells ◽  
Salivary Gland ◽  
T Cell ◽  
Tight Junction ◽  
Sjogren's Syndrome ◽  
Healthy Controls ◽  
Human Salivary Gland ◽  
Semaphorin 4D ◽  
Aqp5 Expression ◽  
Ifn Γ

Background:Semaphorin 4D (SEMA4D) / CD100, known as a subfamily of axonal guidance proteins, has also been reported to act as an immunoregulator in several infectious and inflammatory diseases [1]. Sjögren’s syndrome (SS) is a systemic autoimmune disease that primarily affects the exocrine glands by infiltrated lymphocytes resulting in dryness of mouth and eyes. IL-17 was reported to impair the integrity of tight junction barrier and attenuate the expression of aquaporin 5 (AQP5), causing salivary gland dysfunction in SS [2].Objectives:This study was aimed to evaluate the role of SEMA4D in patients with SS and investigate the effect of SEMA4D on human salivary gland epithelial cell (SGEC) and T cell.Methods:Soluble SEMA4D levels in plasma were measured by enzyme-linked immunosorbent assay (ELISA) from patients with SS, non-SS sicca and healthy controls. Immortalized human SGECs, originated from acini (NS-SV-AC) and duct (NS-SV-DC), were used to evaluate the effects of SEMA4D. CD4+T cells from human peripheral blood were isolated to determine the secretion of cytokines in response to SEMA4D. IFN-γ and IL-17 were used to determine the effects on AQP5 expression of SGEC.Results:The levels of soluble SEMA4D in plasma were increased in patients with SS (median [interquartile range]: 1221.3 [393.5] pg/mL) compared to non-SS sicca (940.2 [355.1] pg/mL,p= 0.006) or healthy controls (909.5 [108.0] pg/mL,p <0.0001). The levels of soluble SEMA4D in plasma were correlated with the levels of several autoantibodies including anti-SSA (Spearman’s rho = 0.358,p= 0.006), anti-SSB (rho = 0.350,p= 0.007), and anti-muscarinic receptor 3 (M3R) Ab (rho = 0.495,p< 0.001), and also correlated with total IgG (rho = 0.431,p= 0.002). SEMA4D-stimulated SGECs showed decreased expression of tight junctions such as occludin and Zo-1. CD4+T cells secreted IFN-γ (p= 0.025), IL-17 (p= 0.028), and IL-21 (p= 0.007) with SEMA4D stimulation. IFN-γ and IL-17 decreased AQP5 expression in SGECs.Conclusion:SEMA4D contributed to decreased expression of tight junction in SGECs. SEMA4D induced production of IFN-γ and IL-17 in CD4+T cells and these cytokine decreased AQP5 expression in SGECs.References:[1]Worzfeld T, Offermanns S. Nat Rev Drug Discov. 2014;13(8):603-21.[2]Bhattarai KR, Junjappa R, Handigund M, Kim HR, Chae HJ. Autoimmun Rev. 2018;17(4):376-90.Disclosure of Interests:None declared

Human salivary gland-specific daily variations in histatin concentrations determined by a novel quantitation technique

2004 ◽  
Vol 49 (1) ◽  
pp. 11-22 ◽  
Author(s):  
Heloisa Gusman ◽  
Cataldo Leone ◽  
Eva J Helmerhorst ◽  
Martha Nunn ◽  
Bianca Flora ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Human Salivary Gland ◽  
Daily Variations

scholarly journals Replication of Oral BK Virus in Human Salivary Gland Cells

2013 ◽  
Vol 88 (1) ◽  
pp. 559-573 ◽  
Author(s):  
R. Burger-Calderon ◽  
V. Madden ◽  
R. A. Hallett ◽  
A. D. Gingerich ◽  
V. Nickeleit ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Bk Virus ◽  
Human Salivary Gland ◽  
Gland Cells ◽  
Salivary Gland Cells

scholarly journals Immunohistochemical localization of carbonic anhydrase III in the pancreas of the monkey.

1989 ◽  
Vol 51 (3) ◽  
pp. 642-645
Author(s):  
Toshiho NISHITA ◽  
Masao ASARI ◽  
Hidetoshi OSHIGE ◽  
Hiroharu MATSUSHITA ◽  
Yutaka KANO
Keyword(s):  
Carbonic Anhydrase ◽  
Immunohistochemical Localization ◽  
Carbonic Anhydrase Iii
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