Dynamics of adrenal morphology and function in irradiated recipients after bone marrow transplantation

1989 ◽  
Vol 107 (6) ◽  
pp. 882-884
Author(s):  
A. A. Tsutsaeva ◽  
T. A. Glushko ◽  
L. E. Shatilova ◽  
N. G. Golubeva
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
And Function

Recipient immune-competent T lymphocytes can survive intensive conditioning for bone marrow transplantation

Blood ◽  
1986 ◽  
Vol 68 (4) ◽  
pp. 954-956 ◽  
Author(s):  
A Butturini ◽  
RC Seeger ◽  
RP Gale
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
T Lymphocytes ◽  
Graft Rejection ◽  
Marrow Transplantation ◽  
Interleukin 2 ◽  
Marrow Transplant ◽  
Effector Cells ◽  
And Function

Abstract Bone marrow transplantation is usually preceded by intensive chemotherapy and radiation therapy designed to completely eliminate recipient immune-competent cells that might reject the donor bone marrow. We show that seven of 14 bone marrow transplant recipients who received intensive conditioning retained circulating T lymphocytes that proliferate after incubation with interleukin 2 and phytohemagglutinin and function as effector cells in an in vitro model of graft rejection. These T cells may mediate graft rejection.

Pediatric Bone Marrow Transplantation: Current Progress and Future Prospects

PEDIATRICS ◽  
1983 ◽  
Vol 72 (6) ◽  
pp. 818-822
Author(s):  
PAUL M. SONDEL ◽  
MICHAEL E. TRIGG ◽  
RICHARD HONG ◽  
JONATHAN L. FINLAY ◽  
MAREK J. BOZDECH
Keyword(s):  
Immune Deficiency ◽  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Aplastic Anemia ◽  
Marrow Transplantation ◽  
Allogeneic Bone Marrow Transplantation ◽  
Allogeneic Bone ◽  
Acute Leukemias ◽  
Term Survival ◽  
And Function

Allogeneic bone marrow transplantation (BMT) has been applied with increasing frequency and success to the treatment of children with severe immune deficiency disease,1,2 aplastic anemia,3,4 and the acute leukemias.5,8 Patients with these otherwise rapidly fatal diseases receive an intravenous infusion of marrow from a healthy donor. The healthy marrow either "replaces" the deficient marrow of children with immune deficiency or aplastic anemia, or "rescues" the marrow of children who have received ablative antileukemic therapy. The resultant engraftment makes the patient a chimera, with reconstitution of mature hematopoietic and immunologic cells of donor origin. When successful, this results in long-term survival with normal marrow function, no recurrence of the original disease, and a return to normal childhood activity and function with only a few irreversible but major side effects (such as infertility following total body irradiation).9

scholarly journals Recipient immune-competent T lymphocytes can survive intensive conditioning for bone marrow transplantation

Blood ◽  
1986 ◽  
Vol 68 (4) ◽  
pp. 954-956 ◽  
Author(s):  
A Butturini ◽  
RC Seeger ◽  
RP Gale
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
T Lymphocytes ◽  
Graft Rejection ◽  
Marrow Transplantation ◽  
Interleukin 2 ◽  
Marrow Transplant ◽  
Effector Cells ◽  
And Function

Bone marrow transplantation is usually preceded by intensive chemotherapy and radiation therapy designed to completely eliminate recipient immune-competent cells that might reject the donor bone marrow. We show that seven of 14 bone marrow transplant recipients who received intensive conditioning retained circulating T lymphocytes that proliferate after incubation with interleukin 2 and phytohemagglutinin and function as effector cells in an in vitro model of graft rejection. These T cells may mediate graft rejection.

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