Functional activity of natural killer cells and killer T cells in mice after ovarian transplantation

1991 ◽  
Vol 112 (3) ◽  
pp. 1281-1283
Author(s):  
A. A. Gaibullaev ◽  
Z. S. Kamalov ◽  
A. V. Madzhidov
Keyword(s):  
T Cells ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Functional Activity ◽  
Killer Cells ◽  
Ovarian Transplantation ◽  
Killer T Cells

In vitro expanded human invariant natural killer T-cells promote functional activity of natural killer cells

2008 ◽  
Vol 129 (1) ◽  
pp. 145-154 ◽  
Author(s):  
María Moreno ◽  
Johan W. Molling ◽  
Silvia von Mensdorff-Pouilly ◽  
René H.M. Verheijen ◽  
B. Mary E. von Blomberg ◽  
...  
Keyword(s):  
T Cells ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Functional Activity ◽  
Natural Killer T Cells ◽  
Killer Cells ◽  
Killer T Cells ◽  
Invariant Natural Killer ◽  
Natural Killer T

scholarly journals In Vivo Survival and Homeostatic Proliferation of Natural Killer Cells

2003 ◽  
Vol 197 (8) ◽  
pp. 967-976 ◽  
Author(s):  
Martin Prlic ◽  
Bruce R. Blazar ◽  
Michael A. Farrar ◽  
Stephen C. Jameson
Keyword(s):  
T Cells ◽  
Natural Killer Cells ◽  
Nk Cells ◽  
Natural Killer ◽  
Cell Sorting ◽  
Functional Activity ◽  
Homeostatic Proliferation ◽  
Killer Cells ◽  
Bystander Cells

While the specificity and development of natural killer (NK) cells have been intensely studied, little is known about homeostasis of the mature NK population. Here we show that mouse NK cells undergo homeostatic proliferation when transferred into NK-deficient Rag−/− γC−/− hosts. Normal NK functional activity is maintained during this process, although there are some changes in NK phenotype. Using cell sorting, we demonstrate that mature (Mac-1hi) NK cells undergo homeostatic proliferation in an NK-deficient environment, yet immature (Mac-1lo) NK cells also proliferate in such hosts. We find that mature NK cells survive but do not proliferate in hosts which possess an endogenous NK pool. However, we go on to show that mature NK survival is critically dependent on interleukin (IL)-15. Surprisingly, NK survival is also compromised after transfer of cells into IL-15Rα−/− mice, implying that IL-15 responsiveness by bystander cells is critical for NK maintenance. These data imply that, similar to T cells, homeostasis of the NK pool is much more dynamic than previously appreciated and this may be relevant to manipulation of NK cells for therapeutic purposes.

Natural killer cells and natural killer T cells in patients with renal transplantation 1

2008 ◽  
Vol 32 (3) ◽  
pp. -
Author(s):  
Anett Hoppe ◽  
Manja Kamprad ◽  
Claudia Wegmann ◽  
Michael Wötzel ◽  
Johann Hauss ◽  
...  
Keyword(s):  
T Cells ◽  
Renal Transplantation ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Natural Killer T Cells ◽  
Killer Cells ◽  
Killer T Cells ◽  
Natural Killer T
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